Aprepitant

Drug ingredient

CAS 170729-80-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

19 FDA-registered drug labelers

Alivus Life Sciences Limited

BluePoint Laboratories

Dr. Reddy's Laboratories Limited

Glenmark Pharmaceuticals Inc., USA

Golden State Medical Supply, Inc.

Heron Therapeutics, Inc.

Hetero Drugs Limited

Inke SA

Jubilant Biosys limited

Merck Sharp & Dohme LLC

MSN Pharmachem Private Limited

Novo Nordisk Production Ireland Limited

OLON ACTIVE PHARMACEUTICAL INGREDIENTS INDIA PRIVATE LIMITED

Optimus Drugs Private Limited

Piramal Pharma Limited

Sandoz Inc

SOLARA ACTIVE PHARMA SCIENCES LIMITED

Torrent Pharmaceuticals Limited

Wisdom Pharmaceutical Co.,Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Emend
•Aprepitant
•Cinvanti
•Aponvie

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Aprepitant Oral Powder for Suspension
Shortage listed since April 8, 2026

See all current drug shortages

Chemical Identity

CAS170729-80-3

PubChem CID135413536

DTXSIDDTXSID3049047

FormulaC23H21F7N4O3

Mol. Weight534.4 g/mol

SMILESCC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F

Data Sources

PubChem · compound 135413536Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Aprepitant (CAS 170729-80-3) https://chemicalindependence.com/chemical/170729-80-3/ PubChem: 135413536. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135413536 FDA National Drug Code directory: CAS 170729-80-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 170729-80-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293499 for CAS 170729-80-3. Reporting year: 2024. https://usatrade.census.gov/