Zanubrutinib

Drug ingredient

CAS 1691249-45-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

9 FDA-registered drug labelers

BeOne Medicines USA, Inc.

Catalent Pharma Solutions, LLC

Esteve Quimica SA

HETERO LABS LIMITED

MSN Laboratories Private Limited

Olon S.p.A.

Shanghai SynTheAll Pharmaceutical Co., Ltd.

Siegfried AG

Siegfried Evionnaz SA

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Brukinsa

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$323.20/gAaron Chemicals LLC

CountryHong Kong

Pack$1616.00 / 5 g

Purity97%

Vendors19 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

18 more vendors

Vendor	Country	$/g	Pack	Purity
BLD Pharmatech Ltd.	China	$333.40	5 g	97%
Angene Chemical	China → Hong Kong	$369.80	5 g	97%
Combi-Blocks (back-ordered)	United States	$455.00	1 g	95%
Ambeed, Inc.	United States	$1280.00	250 mg	97%
BLD Pharmatech Co., Limited	United States	$1280.00	250 mg	97%
A2B Chem LLC	United States	$1500.00	100 mg	97%
AA BLOCKS	United States	$1660.00	100 mg	97%
BLD Pharmatech GmbH	Germany	$2100.00	100 mg	97%
TargetMol Chemicals	China → United States	$2700.00	500 mg	99.09%
Molnova	China	$4230.00	500 mg	99%
TargetMol Chemicals EU	Austria	$4910.00	100 mg	99.55%
AstaTech (2 weeks)	United States	$4950.00	100 mg	95%
TargetMol Chemicals US	United States	$6530.00	100 mg	99.09%
MedKoo Biosciences, Inc	United States	$6750.00	200 mg	98%
MedChemExpress MCE	Sweden	$9873.60	100 mg	99.7%
Angene International Limited	United States	$12970.00	100 mg	98%
Apexbio Technology LLC	United States	$40700.00	10 mg	98.11%
Cayman Europe	Estonia	$60880.40	25 mg	98%

Chemical Identity

CAS1691249-45-2

PubChem CID135565884

DTXSIDDTXSID701026208

FormulaC27H29N5O3

Mol. Weight471.5 g/mol

SMILESC=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N

Data Sources

PubChem · compound 135565884Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Zanubrutinib (CAS 1691249-45-2) https://chemicalindependence.com/chemical/1691249-45-2/ PubChem: 135565884. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135565884 FDA National Drug Code directory: CAS 1691249-45-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 1691249-45-2. Reporting year: 2024. https://usatrade.census.gov/