Metformin hydrochloride
Drug ingredientCAS 1674364-49-8
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Top sourceNo public record
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownWhere It Comes From
EPA and Census publish no US supply data for this chemical.
119 FDA-registered drug labelers
A-S Medication Solutions
ACI Healthcare USA, Inc.
Advanced Rx of Tennessee, LLC
Aesica Queenborough Limited
AiPing Pharmaceutical, Inc.
Ajanta Pharma USA Inc.
American Health Packaging
Amneal Pharmaceuticals Co. (I) Pvt. Ltd.
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
Amneal Pharmaceuticals of New York LLC
Aphena Pharma Solutions - Tennessee, LLC
Ascend Laboratories, LLC
AstraZeneca Pharmaceuticals LP
Aurobindo Pharma Limited
AvKARE
AvPAK
Bionpharma Inc.,
Boehringer Ingelheim Pharma GmbH and Co. KG
Boehringer Ingelheim Pharmaceuticals, Inc.
Bryant Ranch Prepack
Calvin Scott & Co., Inc.
Camber Pharmaceuticals, Inc.
Cambridge Therapeutics Technologies, LLC
Cardinal Health 107, LLC
Chartwell RX, LLC
Coupler LLC
Direct_Rx
Dr.Reddys Laboratories Inc
EPIC PHARMA, LLC
Exemed Pharmaceuticals
Fagron Inc
Farmhispania, S.A.
GLENMARK PHARMACEUTICALS INC., USA
Golden State Medical Supply, Inc.
Granules India Limited
Granules India Ltd
Granules Pharmaceuticals Inc
Harman Finochem Limited
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Ingenus Pharmaceuticals, LLC
IOL Chemicals and Pharmaceuticals Ltd.
Janssen Ortho LLC
Janssen Pharmaceuticals, Inc.
LAURUS LABS LIMITED
Leading Pharma, LLC
Legacy Pharmaceutical Packaging, LLC
LETCO MEDICAL, LLC
Lifsa Drugs, LLC
Lupin Pharmaceuticals, Inc.
Macleods Pharmaceuticals Limited
Major Pharmaceuticals
MARKSANS PHARMA LIMITED
Marlex Pharmaceuticals, Inc.
Medisca Inc.
Merck Sante
Merck Sharp & Dohme LLC
Metcure Pharmaceuticals, Inc.
Method Pharmaceuticals, LLC.
MICRO LABS LIMITED
MSD International GmbH (Puerto Rico Branch) LLC
MSD International GmbH (Singapore Branch)
MSN Life Sciences Private Limited
Mullan Pharmaceutical Inc.
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
Northwind Health Company, LLC
Novadoz Pharmaceuticals LLC
NuCare Pharmaceuticals, Inc.
Oceanside Pharmaceuticals
Padagis Israel Pharmaceuticals Ltd
Patheon Inc.
Patheon Pharmaceuticals Inc.
Patheon Puerto Rico, Inc.
PD-Rx Pharmaceuticals, Inc.
Prasco Laboratories
Precision Dose, Inc.
Preferred Pharmaceuticals Inc
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
PuraCap Laboratories LLC dba Blu Pharmaceuticals
Qingdao BAHEAL Pharmaceutical Co., Ltd.
QPharma, Inc.
Quality Care Products LLC
Quallent Pharmaceuticals Health LLC
RedPharm Drug, Inc.
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Santarus, Inc.
Saptalis Pharmaceuticals, LLC.
ScieGen Pharmaceuticals Inc
Shouguang Fukang Pharmaceutical Co., Ltd.
Sinbiotik, S.A. de C.V.
Solco Healthcare US, LLC.
Spectrum Laboratory Products, Inc.
St. Mary's Medical Park Pharmacy
SUN PHARMACEUTICAL INDUSTRIES, INC.
TAGI Pharma, Inc.
Takeda GmbH
Takeda Pharmaceutical Company LTD
Takeda Pharmaceuticals America, Inc.
Takeda Pharmaceuticals Co LTD
Teva Pharmaceuticals USA, Inc.
TIME CAP LABORATORIES, INC
Torrent Pharmaceuticals Limited
TRUPHARMA, LLC
UNICHEM PHARMACEUTICALS (USA), INC.
UQUIFA Mexico, S.A. DE C.V.
USV Private Limited
VGYAAN Pharmaceuticals LLC
Viona Pharmaceuticals Inc
VistaPharm, LLC
Vistin Pharma AS
Wanbury Limited
Westminster Pharmaceuticals, LLC
Willow Birch Pharma, Inc.
Xenex Laboratories Inc
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 40 drug and cosmetic product listings (FDA).
- •Zituvimet XR
- •Metformin Hydrochloride
- •Metformin HCl
- •Metformin
- •Metformin Hydrochloride Extended Release
- •Jentadueto
- •Synjardy
- •Synjardy XR
Show all 40
- •Trijardy XR
- •glyburide-metformin hydrochloride
- •Glyburide and Metformin Hydrochloride
- •Glipizide and Metformin Hydrochloride
- •Metformin Hydrochloride ER
- •Metformin Hydrochloride Oral Solution
- •Metformin ER 500 mg
- •Metformin ER 750 mg
- •Riomet
- •Segluromet
- •Invokamet
- •Invokamet XR
- •Glipizide and metformin hcl
- •Pioglitazone Hydrochloride and Metformin Hydrochloride
- •Jentadueto XR
- •Janumet XR
- •Saxagliptin and Metformin Hydrochloride
- •Actoplus Met
- •Xigduo XR
- •Saxagliptin and Metformin
- •Linagliptin and metformin hydrochloride
- •Metformin Hydrochloride Extended-Release 500mg
- •Janumet
- •alogliptin and metformin hydrochloride
- •Kazano
- •Sitagliptin and Metformin Hydrochloride
- •Pioglitazone HCL and Metformin HCL
- •dapagliflozin and metformin hydrochloride
- •Glumetza
- •Pioglitazone and metformin hydrochloride
- •Zituvimet
- •Pioglitazole and metformin hydrochloride
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Vendor Pricing
$0.06/gA2B Chem LLC
CountryUnited States
Pack$55.00 / 1 kg
Purity99%
Vendors36 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
35 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| AA BLOCKS | United States | $0.07 | 1 kg | 99% |
| Aaron Chemicals LLC | Hong Kong | $0.07 | 500 g | 97% |
| Angene Chemical | China → Hong Kong | $0.07 | 500 g | 98% |
| Chemscene | United States | $0.08 | 1 kg | — |
| BLD Pharmatech Ltd. | China | $0.08 | 1 kg | 97% |
| Fluorochem UK | United Kingdom | $0.10 | 1 kg | 95% |
| BLD Pharmatech GmbH | Germany | $0.11 | 500 g | 97% |
| BLD Pharmatech Co., Limited | United States | $0.11 | 1 kg | 97% |
| Ambeed, Inc. | United States | $0.11 | 1 kg | 97% |
| Fluorochem EU | Germany | $0.12 | 500 g | 95% |
| Fulfilled by Molport | Latvia | $0.20 | 25 g | 98% |
| AK Scientific Specialized | United States | $0.25 | 1 kg | 98% |
| Combi-Blocks, Inc. | United States | $0.25 | 1 kg | 98% |
| AK Scientific, Inc. | United States | $0.34 | 1 kg | 98.5% |
| AstaTech, Inc | United States | $0.43 | 100 g | 95% |
| Angene International Limited | United States | $0.49 | 100 g | 98% |
| Manchester Organics | United Kingdom | $0.49 | 100 g | — |
| Apollo Scientific UK | United Kingdom | $0.59 | 100 g | 97% |
| MedKoo Biosciences, Inc | United States | $7.00 | 50 g | 98% |
| Cayman Europe | Estonia | $10.95 | 5 g | 98% |
| Life Chemicals Inc. | Ukraine → Canada | $16.00 | 2.5 g | 95% |
| Life Chemicals (Europe) | Germany | $21.00 | 1 g | 95% |
| Sigma-Aldrich (Rush Stock) | Germany | $22.61 | 5 g | 97% |
| Sigma-Aldrich | Germany | $22.61 | 5 g | 97% |
| CliniSciences GmbH | Switzerland | $32.25 | 1 g | 99% |
| Interbioscreen | Hong Kong | $34.00 | 10 g | 95% |
| TargetMol Chemicals | China → United States | $98.00 | 1 g | 99.97% |
| Vitas M Chemical Limited | Hong Kong | $360.00 | 1 g | 90% |
| MedChemExpress MCE | Sweden | $709.06 | 500 mg | 99.98% |
| ChemFaces | China | $1500.00 | 20 mg | 98% |
| Otava, Ltd. | Ukraine | $2724.00 | 50 mg | 90% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
| Key Organics Ltd. | United Kingdom | $8500.00 | 10 mg | 97% |
Chemical Identity
CAS1674364-49-8
PubChem CID14219
DTXSIDDTXSID9037246
FormulaC4H12ClN5
Mol. Weight165.62 g/mol
SMILESCN(C)C(=N)N=C(N)N.Cl
Data Sources
- PubChem · compound 14219Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA National Drug Code directoryRetrieved 2026-04-07
Brief citations
Metformin hydrochloride (CAS 1674364-49-8) https://chemicalindependence.com/chemical/1674364-49-8/ PubChem: 14219. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/14219 FDA National Drug Code directory: CAS 1674364-49-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/