Naltrexone hydrochloride

Drug ingredient

CAS 16676-29-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 16676-29-2 — 1 HCl

US productionNot reported

Import value, 2024$50M

Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark

Canada

45 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare, Inc.

ALMON HEALTHCARE PRIVATE LIMITED

American Health Packaging

Aphena Pharma Solutions - Tennessee, LLC

Aspen Oss B.V.

AvKARE

Bryant Ranch Prepack

Chartwell RX, LLC

DARMERICA, LLC

Elite Laboratories, Inc.

FRANCOPIA

Galenova Inc

Golden State Medical Supply, Inc.

Heritage Pharmaceuticals Inc d/b/a Avet Pharmaceuticals Inc

Kalchem International inc

LETCO MEDICAL, LLC

Major Pharmaceuticals

MEDISCA Inc.

Nalpropion Pharmaceuticals LLC

NCS HealthCare of KY, LLC dba Vangard Labs

Noramco, LLC

NuCare Pharmaceuticals Inc.

NURAY CHEMICALS PRIVATE LIMITED

Pharma Source Direct, Inc.

Precision Dose Inc.

Professional Compounding Centers of America

Professional Compounding Centers of America dba PCCA

Proficient Rx LP

REMEDYREPACK INC.

RUSAN PHARMA LTD

S.A.L.A.R.S. SOCIET AZIONARIA LABORATORI ALCALOIDI RIFORNIMENTI SANITARI S.P.A.

Saneca Pharmaceuticals a.s.

Sanofi Winthrop Industrie

Siegfried AG

Siegfried PharmaChemikalien Minden Gmbh

Siegfried USA, LLC

SpecGx LLC

STHREE CHEMICALS PRIVATE LIMITED

SUN PHARMACEUTICAL INDUSTRIES, INC.

TAGI Pharma Inc.

Wavelength Enterprises Ltd.

Willow Birch Pharma Inc.

Willow Birch Pharma, LLC

Xenex Laboratories Inc

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Naltrexone Hydrochloride
•Contrave Extended-Release

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

resolved
Naltrexone Hydrochloride Tablet
Shortage listed since February 29, 2024

See all current drug shortages

Chemical Identity

CAS16676-29-2

PubChem CID5485201

DTXSIDDTXSID50937236

FormulaC20H24ClNO4

Mol. Weight377.9 g/mol

SMILESC1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O.Cl

Data Sources

PubChem · compound 5485201Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Naltrexone hydrochloride (CAS 16676-29-2) https://chemicalindependence.com/chemical/16676-29-2/ PubChem: 5485201. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5485201 FDA National Drug Code directory: CAS 16676-29-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 16676-29-2. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293919 for CAS 16676-29-2. Reporting year: 2024. https://usatrade.census.gov/