Naltrexone

Drug ingredient

CAS 16590-41-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$50M

Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark

Canada

13 FDA-registered drug labelers

Alkermes, Inc.

Arevipharma GmbH

Noramco, LLC

NURAY CHEMICALS PRIVATE LIMITED

Pharma Source Direct, Inc.

Purisys LLC

Rusan Pharma Ltd

S.A.L.A.R.S. SOCIET AZIONARIA LABORATORI ALCALOIDI RIFORNIMENTI SANITARI S.P.A.

Saneca Pharmaceuticals a.s.

Siegfried AG

SpecGx LLC

STHREE CHEMICALS PRIVATE LIMITED

Wavelength Enterprises Ltd

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

resolved
Naltrexone Hydrochloride Tablet
Shortage listed since February 29, 2024

See all current drug shortages

Chemical Identity

CAS16590-41-3

PubChem CID5360515

DTXSIDDTXSID4046313

FormulaC20H23NO4

Mol. Weight341.4 g/mol

SMILESC1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O

Data Sources

PubChem · compound 5360515Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Naltrexone (CAS 16590-41-3) https://chemicalindependence.com/chemical/16590-41-3/ PubChem: 5360515. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5360515 FDA National Drug Code directory: CAS 16590-41-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 16590-41-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293919 for CAS 16590-41-3. Reporting year: 2024. https://usatrade.census.gov/