C.I. Fluorescent Brightener 220

CAS 16470-24-9

U.S. production volumes are classified as confidential business information.

Molecular structure of 16470-24-9 — 4 Na⁺

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$44M

Import volume14.5M lb

Top sourceIndia 28%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 320420 · basket

EPA reports by year

2023: US production Confidential · Imports 14.5M lb
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 320420, which covers 16 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 28%IndiaCH 26%SwitzerlandTW 22%TaiwanDE 9%GermanyCN 8%China

Indonesia
Italy
Lithuania
Czech Republic
Canada
Sweden
Singapore
Japan
Hong Kong
Netherlands
Hungary
Armenia
Guatemala

EPA-registered manufacturers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Archroma Management Gmbh · CH Switzerland

Archroma U.S

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Tfm North America

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Indulor America

Why It Matters

Sectors

TextilesPaper & Printing

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 2 functional roles.

•Brightener in Paper ManufacturingProcessing—repackaging
•Dye in Paper Manufacturing (100%)Processing—incorporation into article
•Dye in Synthetic Dye and Pigment Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS16470-24-9

PubChem CID6850780

DTXSIDDTXSID4027781

FormulaC40H40N12Na4O16S4

Mol. Weight1165 g/mol

SMILESC1=CC(=CC=C1NC2=NC(=NC(=N2)N(CCO)CCO)NC3=CC(=C(C=C3)C=CC4=C(C=C(C=C4)NC5=NC(=NC(=N5)NC6=CC=C(C=C6)S(=O)(=O)[O-])N(CCO)CCO)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+]

Data Sources

EPA CompTox (DSSTox) · DTXSID4027781Retrieved 2026-04-06
PubChem · compound 6850780Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

C.I. Fluorescent Brightener 220 (CAS 16470-24-9) https://chemicalindependence.com/chemical/16470-24-9/ EPA CompTox (DSSTox): DTXSID4027781. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027781 PubChem: 6850780. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6850780 EPA Chemical Data Reporting: 16470-24-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 16470-24-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 320420 for CAS 16470-24-9. Reporting year: 2024. https://usatrade.census.gov/