Teriflunomide

Drug ingredient

CAS 163451-81-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$281M

Top sourceChina 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292690 · basket

These shares come from HS customs code 292690, which covers 191 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 31%ChinaIT 15%ItalyGB 14%United KingdomIN 11%IndiaJP 8%Japan

South Korea
Spain
Ireland
Ukraine
Malaysia
Brazil
Hong Kong
Latvia
Australia

26 FDA-registered drug labelers

Accord Healthcare Inc.

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Alivus Life Sciences Limited

Aurobindo Pharma Limited

AvKARE

Biocon Limited

Biocon Pharma Inc.

Camber Pharmaceuticals, Inc.

CONCORD BIOTECH LIMITED

Formosa Laboratories, Inc.

Genzyme Corporation

Glenmark Pharmaceuticals Inc., USA

Honour Lab Limited

Maprimed S.A.

MSN LABORATORIES PRIVATE LIMITED

Mylan Pharmaceuticals Inc.

Natco Pharma Limited

Natco Pharma USA LLC

Olon SpA

OPELLA HEALTHCARE INTERNATIONAL SAS

Optimus Drugs Private Limited

Teva Pharmaceuticals, Inc.

Unichem Laboratories Limited, India

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Teriflunomide
•Aubagio

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$72.68/gAstaTech (2 weeks)

CountryUnited States

Pack$1817.00 / 25 g

Purity95%

Vendors5 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

4 more vendors

Vendor	Country	$/g	Pack	Purity
TargetMol Chemicals	China → United States	$480.00	100 mg	99.76%
Fulfilled by Molport	Latvia	$640.00	25 mg	99%
Ramidus AB	Sweden	$1120.00	250 mg	—
Apexbio Technology LLC	United States	$1160.00	100 mg	99.92%

Chemical Identity

CAS163451-81-8

PubChem CID54684141

DTXSIDDTXSID80893457

FormulaC12H9F3N2O2

Mol. Weight270.21 g/mol

SMILESCC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

Data Sources

PubChem · compound 54684141Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Teriflunomide (CAS 163451-81-8) https://chemicalindependence.com/chemical/163451-81-8/ PubChem: 54684141. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/54684141 FDA National Drug Code directory: CAS 163451-81-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292690 for CAS 163451-81-8. Reporting year: 2024. https://usatrade.census.gov/