Methyl tert-butyl ether

Drug ingredient

CAS 1634-04-4

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$117M

Top sourceIndia 29%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290919 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 290919, which covers 93 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 29%IndiaCN 25%ChinaJP 20%JapanBR 6%BrazilDE 4%Germany

South Korea
Singapore
Spain
United Arab Emirates
Netherlands
Belgium
Indonesia
Poland
Mexico
Taiwan
Slovakia

EPA-registered manufacturers (8)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Indorama Netherlands Bv · NL Netherlands

Shell Plc · GB United Kingdom

Enterprise Products Operating

ExxonMobil

Indorama Ventures Usa Holdings

Show all 8

Lyondell Chemical

Shell Petroleum

Tpc Group

Domestic parents -- activity not disclosed (6)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Tartan Oil

Tedia

Total Holdings Usa

Trafigura Trading

Show all 6

Transchem

EPA-registered importers (10)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Bayer Ag · DE Germany

Novasol North America · CA Canada

American River Brokerage

Basf

Show all 10

Bayer Us Holding

Doremus Terminal

Peerless Oil & Chemicals

The Chemical

Univar Solutions Usa

Why It Matters

Sectors

HealthAgricultureEnergyPlastics & RubberConsumer ProductsCore Chemicals

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Industriox
•Industriox 6011
•Enviro Detox Formula

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 7 sectors as 5 functional roles.

•Laboratory chemicals in Pharmaceutical and Medicine Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Intermediate in Petrochemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Fuel in Wholesale and Retail Trade (100%)Processing—incorporation into formulation, mixture, or reaction product
•Fuel agents in Wholesale and Retail Trade (31%)Processing—incorporation into formulation, mixture, or reaction product
•Fuel agents in Petroleum Refineries (30%)Processing—incorporation into formulation, mixture, or reaction product
•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant
•Fuel agents in Petrochemical Manufacturing (25%)Processing—incorporation into formulation, mixture, or reaction product
•Fuel in Petroleum Refineries (35%)Processing—incorporation into formulation, mixture, or reaction product
•Laboratory chemicals in Wholesale and Retail TradeNot Known or Reasonably Ascertainable
•Laboratory chemicals in ServicesNot Known or Reasonably Ascertainable
•Solvent in Pesticide, Fertilizer, and Other Agricultural Chemical ManufacturingProcessing as a reactant
•Fuel agents in All Other Basic Organic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Solvent in Pharmaceutical and Medicine Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS1634-04-4

PubChem CID15413

DTXSIDDTXSID3020833

FormulaC5H12O

Mol. Weight88.15 g/mol

SMILESCC(C)(C)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID3020833Retrieved 2026-04-06
PubChem · compound 15413Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Methyl tert-butyl ether (CAS 1634-04-4) https://chemicalindependence.com/chemical/1634-04-4/ EPA CompTox (DSSTox): DTXSID3020833. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020833 PubChem: 15413. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/15413 EPA Chemical Data Reporting: 1634-04-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 1634-04-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290919 for CAS 1634-04-4. Reporting year: 2024. https://usatrade.census.gov/