Ezetimibe

Drug ingredient

CAS 163222-33-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

41 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare Inc.

Actavis Pharma, Inc.

Alivus Life Sciences Limited

American Health Packaging

Amneal Pharmaceuticals NY LLC

Ascend Laboratories, LLC

Aurobindo Pharma Limited

AvKARE

AvPAK

Bryant Ranch Prepack

Camber Pharmaceuticals, Inc.

Dasami Lab Private Limited

Dr. Reddy's Laboratories Limited

Dr.Reddys Laboratories Inc

Esperion Therapeutics, Inc.

Glenmark Pharmaceuticals Inc., USA

Golden State Medical Supply, Inc.

HETERO LABS LIMITED

Macleods Pharmaceuticals Limited

Major Pharmaceuticals

Marlex Pharmaceuticals, Inc.

MSD International GmbH (Singapore Branch)

MSN Laboratories Private Limited

Nantong Chanyoo Pharmatech Co., Ltd

Neuland Laboratories Limited

NORTHSTAR RX LLC

Ohm Laboratories Inc.

Organon LLC

ORGANON PHARMA (UK) LIMITED

Orient Pharma Co., Ltd.

Piramal Pharma Limited

Proficient Rx LP

Quallent Pharmaceuticals Health LLC

Sandoz Inc

ScieGen Pharmaceuticals Inc

Symed Labs Limited

Synthimed Labs Private Limited

Teva API India Private Ltd

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Ezetimibe
•Ezetimibe and Simvastatin
•Vytorin
•Nexlizet
•Zetia

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Ezetimibe Tablet
Shortage listed since June 27, 2025

See all current drug shortages

Chemical Identity

CAS163222-33-1

PubChem CID150311

DTXSIDDTXSID1044223

FormulaC24H21F2NO3

Mol. Weight409.4 g/mol

SMILESC1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O

Data Sources

PubChem · compound 150311Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ezetimibe (CAS 163222-33-1) https://chemicalindependence.com/chemical/163222-33-1/ PubChem: 150311. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/150311 FDA National Drug Code directory: CAS 163222-33-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 163222-33-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293379 for CAS 163222-33-1. Reporting year: 2024. https://usatrade.census.gov/