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Roflumilast

Drug ingredient

CAS 162401-32-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 162401-32-3
US productionNot reported
Import value, 2024$1.3B
Top sourceChina 32%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293339 · basket

These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland
29 FDA-registered drug labelers
Alivus Life Sciences Limited
American Health Packaging
Amici Pharma Inc.
Arcutis Biotherapeutics, Inc.
Ascend Laboratories, LLC
AstraZeneca Pharmaceuticals LP
Aurobindo Pharma Limited
AX Pharmaceutical Corp
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Corden Pharma GmbH
Golden State Medical Supply, Inc.
Hetero Drugs Limited
Interquim, S.A.
Jubilant Cadista Pharmaceuticals Inc.
MAJOR PHARMACEUTICALS
Micro Labs Limited
MSN Laboratories Private Limited
MYLAN LABORATORIES LIMITED
Novadoz Pharmaceuticals LLC
SciAnda(Changshu) Pharmaceuticals, Ltd.
ScinoPharm Taiwan Ltd.
Sintenovo SA de CV
Solco Healthcare US, LLC.
Strides Pharma Science Limited
Takeda GmbH
Viyash Life Sciences Private Limited
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Roflumilast
  • •Daliresp
  • •Zoryve
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$10.52/gA2B Chem LLC
CountryUnited States
Pack$263.00 / 25 g
Purity99%
Vendors27 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

26 more vendors
VendorCountry$/gPackPurity
Aaron Chemicals LLCHong Kong$10.9625 g98%
AA BLOCKSUnited States$11.7225 g99%
Angene ChemicalChina → Hong Kong$12.6025 g97%
BLD Pharmatech Co., LimitedUnited States$12.80100 g99%
BLD Pharmatech Ltd.China$12.80100 g99%
Ambeed, Inc.United States$12.80100 g99%
Combi-Blocks, Inc.United States$12.80100 g98%
BLD Pharmatech GmbHGermany$14.8025 g99%
AK Scientific SpecializedUnited States$15.2825 g95%
AstaTech, IncUnited States$15.9225 g95%
AK Scientific, Inc.United States$20.3625 g98%
Accela ChemBioUnited States$24.001 g97%
MedKoo Biosciences, IncUnited States$490.005 g98%
ChemFacesChina$1500.0020 mg98%
MedChemExpress MCESweden$1998.92500 mg99.98%
MolnovaChina$2380.00100 mg99%
TargetMol ChemicalsChina → United States$2640.00100 mg99.99%
Angene International LimitedUnited States$3060.00100 mg99%
AngeneChina → Hong Kong$4266.6730 mg97%
Ramidus ABSweden$5040.0050 mg—
Apexbio Technology LLCUnited States$5060.0050 mg99.08%
Axon MedchemNetherlands$6720.0050 mg100%
Sigma-Aldrich (Rush Stock)Germany$8740.4050 mg98%
Sigma-AldrichGermany$8740.4050 mg98%
Cayman EuropeEstonia$13042.4025 mg98%
Key Organics Ltd.United Kingdom$17200.0010 mg97%

Chemical Identity

CAS162401-32-3
PubChem CID449193
DTXSIDDTXSID8044123
FormulaC17H14Cl2F2N2O3
Mol. Weight403.2 g/mol
SMILESC1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F

Data Sources

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Brief citations

Roflumilast (CAS 162401-32-3) https://chemicalindependence.com/chemical/162401-32-3/ PubChem: 449193. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/449193 FDA National Drug Code directory: CAS 162401-32-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293339 for CAS 162401-32-3. Reporting year: 2024. https://usatrade.census.gov/