Clonazepam

Drug ingredientActive Shortage

CAS 1622-61-3

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$10M

Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland

China
Switzerland
Germany

35 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare Inc.

Advagen Pharma Ltd

Advanced Rx of Tennessee, LLC

Advanced Rx Pharmacy of Tennessee, LLC

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

American Health Packaging

Aphena Pharma Solutions - Tennessee, LLC

Aurobindo Pharma Limited

AvPAK

Bryant Ranch Prepack

Cambrex Profarmaco Milano Srl

Cardinal Health 107, LLC

Centaur Pharmaceuticals Private Limited

Chartwell RX, LLC

Clinical Solutions Wholesale, LLC

Coupler LLC

DIRECT RX

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

H2-Pharma, LLC

Major Pharmaceuticals

Northstar Rx LLC

NuCare Pharmaceuticals,Inc.

Par Health USA, LLC

PD-Rx Pharmaceuticals, Inc.

Preferred Pharmaceuticals Inc.

Professional Compounding Centers of America

Proficient Rx LP

R.L.Fine Chem Private Limited

REMEDYREPACK INC.

Solco Healthcare LLC

St Marys Medical Park Pharmacy

SUN PHARMACEUTICAL INDUSTRIES, INC.

Teva Pharmaceuticals USA, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Clonazepam
•Klonopin

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Clonazepam Tablet
Shortage listed since March 10, 2023
Manufacturer reports: 1 limited, 2 available, 1 information pending

See all current drug shortages

Chemical Identity

CAS1622-61-3

PubChem CID2802

DTXSIDDTXSID1022845

FormulaC15H10ClN3O3

Mol. Weight315.71 g/mol

SMILESC1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl

Data Sources

PubChem · compound 2802Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Clonazepam (CAS 1622-61-3) https://chemicalindependence.com/chemical/1622-61-3/ PubChem: 2802. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2802 FDA National Drug Code directory: CAS 1622-61-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 1622-61-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293391 for CAS 1622-61-3. Reporting year: 2024. https://usatrade.census.gov/