Everolimus

Drug ingredient

CAS 159351-69-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

23 FDA-registered drug labelers

Amneal Pharmaceuticals NY LLC

Ascend Laboratories, LLC

Aurobindo Pharma Limited

Biocon Limited

Biocon Pharma Inc.

Breckenridge Pharmaceutical, Inc.

BrightGene Bio-Medical Technology Co., Ltd.

Chunghwa Chemical Synthesis & Biotech. Ltd

Chunghwa Chemical Sysnthsis & Biotech Co.,Ltd.

CONCORD BIOTECH LTD

Dr. Reddy's Laboratories Limited

Farmhispania, S.A.

Hikma Pharmaceuticals USA Inc.

MSN Laboratories Private Limited

NATCO PHARMA LIMITED

NorthStar RxLLC

Novartis Pharma Stein AG

Novartis Pharmaceuticals Corporation

Novugen Pharma (USA) LLC.

Par Health USA, LLC

ScinoPharm Taiwan Ltd.

Teva Pharmaceuticals USA, Inc.

Upsher-Smith Laboratories, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Zortress
•Afinitor
•Everolimus
•Afinitor Disperz
•Torpenz

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Everolimus Tablet
Shortage listed since November 3, 2025

See all current drug shortages

Chemical Identity

CAS159351-69-6

PubChem CID6442177

DTXSIDDTXSID0040599

FormulaC53H83NO14

Mol. Weight958.2 g/mol

SMILESCC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC

Data Sources

PubChem · compound 6442177Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Everolimus (CAS 159351-69-6) https://chemicalindependence.com/chemical/159351-69-6/ PubChem: 6442177. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6442177 FDA National Drug Code directory: CAS 159351-69-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 159351-69-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293499 for CAS 159351-69-6. Reporting year: 2024. https://usatrade.census.gov/