Tolvaptan

Drug ingredient

CAS 150683-30-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.4B

Top sourceIreland 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy

Taiwan
Poland
Canada
Ivory Coast
Greece
Hungary
Indonesia
Latvia
Belgium
Slovakia
Czech Republic
Austria
Netherlands
Finland
Denmark
Croatia
Australia
South Africa
Sweden
Hong Kong
Malta
Singapore
Lithuania
Malaysia
Oman
Serbia

14 FDA-registered drug labelers

Apotex Corp.

Ascend Laboratories, LLC

Aurore Pharmaceuticals Private Limited

Camber Pharmaceuticals, Inc.

Endo USA, Inc.

Hetero Drugs Limited

HETERO LABS LIMITED

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Lupin Pharmaceuticals, Inc.

MSN Laboratories Private Limited

Novadoz Pharmaceuticals LLC

Otsuka America Pharmaceutical, Inc.

OTSUKA PHARMACEUTICAL CO., LTD.

TYCHE INDUSTRIES LIMITED

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Tolvaptan
•Jynarque
•Samsca

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$19.50/gCombi-Blocks, Inc.

CountryUnited States

Pack$1950.00 / 100 g

Purity97%

Vendors14 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

13 more vendors

Vendor	Country	$/g	Pack	Purity
AK Scientific Specialized	United States	$32.88	25 g	98%
Fulfilled by Molport	Latvia	$62.00	1 g	95%
AstaTech, Inc	United States	$590.00	100 mg	99%
MedKoo Biosciences, Inc	United States	$2625.00	2 g	98%
AK Scientific, Inc.	United States	$4970.00	100 mg	99%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
Apexbio Technology LLC	United States	$7260.00	50 mg	99.81%
TargetMol Chemicals	China → United States	$7660.00	50 mg	99.99%
Axon Medchem	Netherlands	$8640.00	50 mg	99%
MedChemExpress MCE	Sweden	$9123.40	100 mg	99.95%
Cayman Europe	Estonia	$21134.40	25 mg	98%
Sigma-Aldrich (Rush Stock)	Germany	$28733.60	25 mg	98%
Sigma-Aldrich	Germany	$28733.60	25 mg	98%

Chemical Identity

CAS150683-30-0

PubChem CID216237

DTXSIDDTXSID3048780

FormulaC26H25ClN2O3

Mol. Weight448.9 g/mol

SMILESCC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

Data Sources

PubChem · compound 216237Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tolvaptan (CAS 150683-30-0) https://chemicalindependence.com/chemical/150683-30-0/ PubChem: 216237. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/216237 FDA National Drug Code directory: CAS 150683-30-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 150683-30-0. Reporting year: 2024. https://usatrade.census.gov/