Pemetrexed disodium

Drug ingredient

CAS 150399-23-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 150399-23-8 — 2 Na⁺

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

14 FDA-registered drug labelers

Apotex Corp

BluePoint Laboratories

Dr. Reddys Laboratories Inc

Dr.Reddys Laboratories Limited

Fresenius Kabi USA, LLC

Hospira, Inc.

Huzhou Zhanwang Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

Sandoz Inc.

Shandong Anhong Pharmaceutical Co., Ltd.

SHILPA PHARMA LIFESCIENCES LIMITED

Suzhou Lixin Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•pemetrexed
•Pemetrexed disodium

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Pemetrexed Disodium Injection
Shortage listed since October 10, 2025

See all current drug shortages

Chemical Identity

CAS150399-23-8

PubChem CID135413520

DTXSIDDTXSID8046660

FormulaC20H19N5Na2O6

Mol. Weight471.4 g/mol

SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Data Sources

PubChem · compound 135413520Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Pemetrexed disodium (CAS 150399-23-8) https://chemicalindependence.com/chemical/150399-23-8/ PubChem: 135413520. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135413520 FDA National Drug Code directory: CAS 150399-23-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 150399-23-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293359 for CAS 150399-23-8. Reporting year: 2024. https://usatrade.census.gov/