Sacubitril

Drug ingredient

CAS 149709-62-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$872M

Top sourceSwitzerland 44%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292429 · basket

These shares come from HS customs code 292429, which covers 203 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 44%SwitzerlandCN 19%ChinaIN 12%IndiaJP 9%JapanIE 6%Ireland

Taiwan
United Kingdom
El Salvador
Colombia
Ukraine
Brazil
Guatemala
Belgium
Netherlands
Turkey
Sweden
Greece
Canada
Israel
New Zealand
Latvia
Lithuania
Finland
Slovakia
Australia
Hong Kong
Czech Republic
Armenia
Poland

29 FDA-registered drug labelers

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Amneal Pharmaceuticals NY LLC

ANI Pharmaceuticals, Inc.

Aphena Pharma Solutions - Tennessee, LLC

Ascend Laboratories, LLC

AvKARE

AvPAK

Biocon Limited

Biocon Pharma Inc.

Camber Pharmaceuticals, Inc.

Chunghwa Chemical Synthesis & Biotech. Ltd

Coupler LLC

Dr. Reddy's Laboratories Inc.

Haleos Labs Limited

Laurus Labs Limited

Lupin Pharmaceuticals, Inc.

Macleods Pharmaceuticals Limited

Major Pharmaceuticals

MSN Life Sciences Private Limited

Novadoz Pharmaceuticals LLC

Novartis Pharmaceuticals Corporation

Novugen Pharma (USA) LLC

Somerset Therapeutics, LLC

Torrent Pharmaceuticals Limited

XLCare Pharmaceuticals Inc

Zhuhai Rundu Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•sacubitril and valsartan
•Entresto
•Sacubitril and Valsartan Sacubitril and Valsartan

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS149709-62-6

PubChem CID9811834

DTXSIDDTXSID20164370

FormulaC24H29NO5

Mol. Weight411.5 g/mol

SMILESCCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O

Data Sources

PubChem · compound 9811834Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Sacubitril (CAS 149709-62-6) https://chemicalindependence.com/chemical/149709-62-6/ PubChem: 9811834. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9811834 FDA National Drug Code directory: CAS 149709-62-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292429 for CAS 149709-62-6. Reporting year: 2024. https://usatrade.census.gov/