leucovorin calcium

Drug ingredient

CAS 1492-18-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1492-18-8 — 1 Ca²⁺

US productionNot reported

Import value, 2024$295M

Top sourceChina 56%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293629 · basket

These shares come from HS customs code 293629, which covers 17 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 56%ChinaCH 12%SwitzerlandIN 12%IndiaIT 11%ItalyJP 2%Japan

Spain
Netherlands
Czech Republic
Israel
Guyana
Norway
Australia
Taiwan
Ivory Coast
Honduras
South Korea
Austria
Colombia
Brazil
Mexico
Belgium
South Africa
Turkey
Hong Kong
Chile
Slovenia
Ecuador
Sweden
Vietnam

31 FDA-registered drug labelers

American Health Packaging

Avyxa Pharma, LLC

AX Pharmaceutical Corp

BluePoint Laboratories

Cerbios-Pharma SA

Epic Pharma LLC

FARMASIERRA MANUFACTURING SL

Fresenius Kabi USA, LLC

Gland Pharma Limited

GLENMARK PHARMACEUTICALS INC., USA

GMT Fine Chemicals SA

Hikma Pharmaceuticals USA Inc.

Huzhou Zhanwang Pharmaceutical Co., Ltd.

Ingenus Pharmaceuticals, LLC

Leading Pharma, LLC

LETCO MEDICAL, LLC

Major Pharmaceuticals

Meitheal Pharmaceuticals Inc.

MERCK & CIE

MOLCLONE LABS PRIVATE LIMITED

Mylan Institutional LLC

Pfizer Laboratories Div Pfizer Inc

Professional Compounding Centers of America

Professional Compounding Centers of America dba PCCA

Proficient Rx LP

Qingdao Biopeptek Co., Ltd.

Sagent Pharmaceuticals

Slate Run Pharmaceuticals, LLC

Spectrum Laboratory Products, Inc.

Teva Pharmaceuticals USA, Inc.

Willow Birch Pharma, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•leucovorin calcium
•Vykoura
•Lederle Leucovorin

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1492-18-8

PubChem CID135403647

DTXSIDDTXSID20872448

FormulaC20H21CaN7O7

Mol. Weight511.5 g/mol

SMILESC1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]

Data Sources

PubChem · compound 135403647Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

leucovorin calcium (CAS 1492-18-8) https://chemicalindependence.com/chemical/1492-18-8/ PubChem: 135403647. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135403647 FDA National Drug Code directory: CAS 1492-18-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293629 for CAS 1492-18-8. Reporting year: 2024. https://usatrade.census.gov/