Trimethoxymethane

CAS 149-73-5

Companies reported imports and no US production of this chemical to EPA for 2023.

US productionZero

Import value, 2024$384M

Import volume1.3K lb

Import dependency100%

Top sourceMalaysia 21%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Trimethoxymethane · US import value by year

2013: $222M · Peak 2021: $1.6B · 2024: $384M · 2025: $365M

Where It Comes From

Customs basis: HS 291590 · basket

EPA reports by year

2023: US production Zero · Imports 1.3K lb
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy

Singapore
Austria
United Kingdom
Philippines
Canada
Hungary
Turkey
Ukraine
Israel
Denmark
Czech Republic
Slovakia
Norway
Poland
Hong Kong
South Africa
Russia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Aceto Us

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Cbc America

Why It Matters

Sectors

Agriculture

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$0.07/gManchester Organics

CountryUnited Kingdom

Pack$176.26 / 2.5 kg

Purity99%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$0.09	500 g	99%
AK Scientific Specialized	United States	$0.13	500 g	95%
AK Scientific, Inc.	United States	$0.17	500 g	98%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
A2B Chem LLC	United States	$0.27	1 kg	98%
Interbioscreen	Hong Kong	$24.00	10 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%

Chemical Identity

CAS149-73-5

PubChem CID9005

DTXSIDDTXSID7027122

FormulaC4H10O3

Mol. Weight106.12 g/mol

SMILESCOC(OC)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID7027122Retrieved 2026-04-06
PubChem · compound 9005Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Trimethoxymethane (CAS 149-73-5) https://chemicalindependence.com/chemical/149-73-5/ EPA CompTox (DSSTox): DTXSID7027122. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027122 PubChem: 9005. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/9005 EPA Chemical Data Reporting: 149-73-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 149-73-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291590 for CAS 149-73-5. Reporting year: 2024. https://usatrade.census.gov/