Flag of the United StatesAmerican Chemical Independence

L-Proline

Drug ingredient

CAS 147-85-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 147-85-3
US production25.1K lb
Import volumeZero
Import dependency0%
Top sourceNo public record

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

EPA reports by year
2023
US production 25.1K lb · Imports Zero
2019
US production Zero · Imports 46.4K lb

HS customs code 293399 covers 518 tracked chemicals in total. US Census does not break out this chemical's share, so the country-of-origin mix is not available. EPA CDR reports import dependency at the chemical level separately, shown above.

EPA-registered manufacturers (1)
Life Technologies

Why It Matters

Sectors
Health
Downstream Uses

Appears in 16 drug and cosmetic product listings (FDA).

  • •Aminosyn-PF
  • •Plenamine
  • •Kabiven
  • •Clinimix
  • •Clinimix E
  • •Clinisol
  • •ProSol
  • •TrophAmine
Show all 16
  • •TH-101
  • •Aminosyn II
  • •Metabatone
  • •Vital Skin Hair Nails
  • •Travasol
  • •Perikabiven
  • •Metab
  • •Premasol - sulfite-free (Amino Acid)
FDA Shortage Status
No FDA shortage records

Industrial Uses

  • •Catalyst in Pharmaceutical and Medicine ManufacturingUse—non-incorporative activities

Vendor Pricing

$0.09/gAaron Chemicals LLC
CountryHong Kong
Pack$43.00 / 500 g
Purity98%
Vendors30 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

29 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.091 kg98%
A2B Chem LLCUnited States$0.09500 g98%
AA BLOCKSUnited States$0.11500 g98%
ChemsceneUnited States$0.131 kg—
BLD Pharmatech Co., LimitedUnited States$0.141 kg98%
BLD Pharmatech GmbHGermany$0.141 kg98%
BLD Pharmatech Ltd.China$0.141 kg98%
Ambeed, Inc.United States$0.141 kg98%
Fluorochem EUGermany$0.15500 g98%
Fluorochem UKUnited Kingdom$0.15500 g98%
AstaTech, IncUnited States$0.19500 g98%
MedChemExpress MCESweden$0.23500 g98%
AK Scientific SpecializedUnited States$0.251 kg95%
Combi-Blocks, Inc.United States$0.251 kg98%
AK Scientific, Inc.United States$0.351 kg99%
Acrotein ChemBio, Inc.United States$0.42250 g—
Manchester OrganicsUnited Kingdom$0.42250 g—
Angene International LimitedUnited States$0.49100 g98%
Sigma-Aldrich (Rush Stock)Germany$5.1925 g99%
Sigma-AldrichGermany$5.1925 g99%
MolnovaChina$76.00500 mg99%
Labotest KGGermany$217.805000 mg90%
ChemFacesChina$1500.0020 mg98%
Otava, Ltd.Ukraine$1840.00250 mg95%
Princeton BioMolecular Research (SC)United States$4200.0050 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
Vitas M Chemical LimitedHong Kong$6250.0020 mg90%
Life Chemicals Inc.Ukraine → Canada$9900.0010 mg90%
TimTec, LLC (back-ordered)United States$32000.0015 mg94%

Chemical Identity

CAS147-85-3
PubChem CID145742
DTXSIDDTXSID5044021
FormulaC5H9NO2
Mol. Weight115.13 g/mol
SMILESC1CC(NC1)C(=O)O

Data Sources

← Back to Dashboard← Back to Health

Brief citations

L-Proline (CAS 147-85-3) https://chemicalindependence.com/chemical/147-85-3/ EPA CompTox (DSSTox): DTXSID5044021. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044021 PubChem: 145742. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/145742 EPA Chemical Data Reporting: 147-85-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 147-85-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting