diphenhydramine hcl

Drug ingredient

CAS 147-24-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$197M

Top sourceChina 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary

Saudi Arabia
Lithuania
Canada
Ukraine
Israel
Singapore
Mexico
Ireland
Netherlands
Malaysia
Slovakia
Denmark
Finland
Latvia
Greece
Austria

10 FDA-registered drug labelers

A-S Medication Solutions

Amerisource Bergen

Best Choice

BI-MART

Grocery Outlet

Kenvue Brands LLC

Kesin Pharma Corporation

Rnv LLC

The Procter & Gamble Manufacturing Company

Topco Associates, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 11 drug and cosmetic product listings (FDA).

•Dye Free Allergy Relief
•Revasol Sleep AID
•Allergy Relief
•Diphenhydramine Hydrochloride
•Revasol Childrens Allergy
•Childrens Allergy Relief
•Vicks PainQuil PM Liquicaps PAIN Reliever plus Nighttime Sleep-AID
•Benadryl Allergy Extra Strength Liqui-Gels

Show all 11

•Diphenhydramine HCl Oral Solution
•Diphenhydramine HCl
•GNP Extra Strength Anti-Itch Cream

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS147-24-0

PubChem CID8980

DTXSIDDTXSID4020537

FormulaC17H22ClNO

Mol. Weight291.8 g/mol

SMILESCN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Data Sources

PubChem · compound 8980Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

diphenhydramine hcl (CAS 147-24-0) https://chemicalindependence.com/chemical/147-24-0/ PubChem: 8980. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/8980 FDA National Drug Code directory: CAS 147-24-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292219 for CAS 147-24-0. Reporting year: 2024. https://usatrade.census.gov/