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Pralatrexate

Drug ingredient

CAS 146464-95-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 146464-95-1
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
7 FDA-registered drug labelers
Acrotech Biopharma Inc
Curia New York, Inc.
Dr.Reddy's Laboratories Inc.,
Fresenius Kabi USA, LLC
Hetero Labs Limited
Sicor S.r.l.
Teva Czech Industries s.r.o

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Pralatrexate
  • •Folotyn
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS146464-95-1
PubChem CID148121
DTXSIDDTXSID3048578
FormulaC23H23N7O5
Mol. Weight477.5 g/mol
SMILESC#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Data Sources

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Brief citations

Pralatrexate (CAS 146464-95-1) https://chemicalindependence.com/chemical/146464-95-1/ PubChem: 148121. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/148121 FDA National Drug Code directory: CAS 146464-95-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 146464-95-1. Reporting year: 2024. https://usatrade.census.gov/