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Yohimbine

Drug ingredient

CAS 146-48-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 146-48-5
US productionNot reported
Import value, 2024$171M
Top sourceSwitzerland 40%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293979 · basket

These shares come from HS customs code 293979, which covers 60 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 40%SwitzerlandCN 18%ChinaIT 14%ItalyDE 13%GermanyIN 10%India
3 FDA-registered drug labelers
Bestmade Natural Products
OHM PHARMA INC.
Professional Complementary Health Formulas

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •Libido Stim Liquescence 3014
  • •OHM-DAM
  • •Aralia Combination 9256
  • •Bestmade Natural Products Testosterone Support
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS146-48-5
PubChem CID8969
DTXSIDDTXSID9040130
FormulaC21H26N2O3
Mol. Weight354.4 g/mol
SMILESCOC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O

Data Sources

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Brief citations

Yohimbine (CAS 146-48-5) https://chemicalindependence.com/chemical/146-48-5/ PubChem: 8969. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/8969 FDA National Drug Code directory: CAS 146-48-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293979 for CAS 146-48-5. Reporting year: 2024. https://usatrade.census.gov/