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Lorlatinib

Drug ingredient

CAS 1454846-35-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1454846-35-5
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
3 FDA-registered drug labelers
Pfizer Laboratories Div Pfizer Inc
Pfizer Manufacturing Deutschland GmbH (Betriebssttte Freiburg)
U.S. Pharmaceuticals

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Lorbrena
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS1454846-35-5
PubChem CID71731823
DTXSIDDTXSID201027944
FormulaC21H19FN6O2
Mol. Weight406.4 g/mol
SMILESCC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

Data Sources

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Brief citations

Lorlatinib (CAS 1454846-35-5) https://chemicalindependence.com/chemical/1454846-35-5/ PubChem: 71731823. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71731823 FDA National Drug Code directory: CAS 1454846-35-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 1454846-35-5. Reporting year: 2024. https://usatrade.census.gov/