Sodium bicarbonate
Drug ingredientActive ShortageCAS 144-55-8
This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$37M
Top sourceGermany 55%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.
Where It Comes From
Customs basis: HS 283630 · exact
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
Source Countries
Country of origin for US imports, from Census customs data (2024).
DE 55%GermanyMX 10%MexicoES 9%SpainIT 8%ItalyCA 7%Canada
- United Kingdom
- Brazil
- Czech Republic
- South Korea
- Israel
- Colombia
- Ukraine
- Croatia
- Switzerland
- Poland
- Singapore
- Australia
- Honduras
EPA-registered manufacturers (5)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Dynachem
Ecolab
Genesis Energy
Gulf Coast Growth Ventures
Minerals Technologies
Domestic parents -- activity not disclosed (1)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Carbonfree Chemicals Spe 1 Holdings
EPA-registered importers (16)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Clariant International · CH Switzerland
Reckitt Benckiser Group · GB United Kingdom
Avient
Brenntag
Clariant
Show all 16
Gsd Distribution
Honeywell International (123312)
Ineos Styrolution America
Johnson Matthey
Kidde Residential & Commercial
Kik International
Quadra Chemicals
Reckitt Benckiser
Solenis
Target
Uzin Utz North America
131 FDA-registered drug labelers
78271
A-S Medication Solutions
Advanced Rx LLC
Adventure Ready Brands
Affordable Pharmaceuticals, LLC
Ajanta Pharma USA Inc.
Alivus Life Sciences Limited
Amazon.com Services LLC
Amneal Pharmaceuticals Private Limited
ANI Pharmaceuticals, Inc.
Anthea Pharma Private Limited
Apex Energetics Inc.
Aphena Pharma Solutions - Tennessee, LLC
APNAR PHARMA LP
Aqua Medica, S.A. de C.V.
ASCENT CONSUMER PRODUCTS, INC.
Aurohealth LLC
Avantor Performance Materials, LLC
Bayer HealthCare LLC.
Bestmade Natural Products
BETTER LIVING BRANDS LLC
Beutlich Pharmaceuticals, LLC
BM Private Limited
Braintree Laboratories, Inc.
Bryant Ranch Prepack
Cardinal Health
Cardinal Health 107, LLC
Cardinal Health, 110 dba LEADER
Carolina Cannabis Creations LLC
Chain Drug Marketing Association
Chang Kuo Chou Pharmaceutical Co., Ltd.
Church & Dwight Co., Inc.
Cipla USA Inc.
CitraGen Pharmaceuticals Inc.
Civica
Cosmuses Cosmetics (Ningbo) Co., Ltd.
CVS Pharmacy
Demoulas Super Markets, Inc.
Direct_rx
Discount Drug Mart, Inc
DLC LABORATORIES, INC.
DOLGENCORP, INC
Dr. Reddy's Laboratories Inc.,
E-Z-EM, INC.
EMNAR PHARMA PRIVATE LIMITED
Energetix Corporation
Evi Labs
Exela Pharma Sciences, LLC
FOODHOLD U.S.A.
Fresenius Kabi USA, LLC
Gendose Pharmaceuticals, LLC
Glenmark Pharmaceuticals Inc., USA
Good Sense
GRAXCELL PHARMACEUTICAL, LLC
Guardian Drug Company
GURUNANDA LLC
H E B
H. E. Butt Grocery Company
Henry Schein, Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hospira, Inc.
Huber Soda, LLC (DBA Natrium Products)
Humco Holding Group, Inc
International Medication Systems, Limited
JC World Bell Wholesale Co., Inc.
Kroger Company
L. Perrigo Company
Lil' Drug Store Products, Inc.
Long Grove Pharmaceuticals, LLC
Lotus Brands, Inc.
Lukare Medical, LLC
Lupin Pharmaceuticals,Inc.
Maithri Drugs Private Limited
Major Pharmaceuticals
Medical Purchasing Solutions, LLC
Meijer Distribution Inc
Meijer, Inc.
Menper Distributors Inc.
Navajo Manufacturing Company Inc.
NORTHSTAR RX LLC
Novel Laboratories, Inc.
Oceanside Pharmaceuticals
OHTA'S ISAN CO.,LTD.
OMNIVIUM PHARMACEUTICALS LLC.
Onion Culture Industrial Co., Limited
Pharma Nobis, LLC
Pharmadel LLC
PHOENIX RX LLC
Proficient Rx LP
ProPharma Distribution
Publix Super Markets Inc.
R J General Corporation
RB Health Mexico, S.A. de C.V.
Reliable 1 Laboratories LLC
REMEDYREPACK INC.
Richmond Pharmaceuticals, Inc.
Riley Consumer Care LLC
Rising Pharma Holdings, Inc.
Rite Aid
RITE AID CORPORATION
Rugby Laboratories
Safeway, Inc
Santarus, Inc..
Sato Pharmaceutical Co., Ltd.
ScieGen Pharmaceuticals, Inc.
Select Consumer Group
Shenzhen Kerui lntl Trading Co., Ltd
Shenzhen Shierjie Biological Engineering Co., LTD
Spectrum Laboratory Products, Inc.
Steriscience Specialties Private Limited
Strides Pharma Science Limited
Sun Pharmaceutical Industries Limited
Target Corporation
Tender Corporation d/b/a Adventure Ready Brands
Topco Associates LLC
Tower Laboratories Ltd
TWIN MED LLC
Unifirst First Aid Corporation
United Natural Foods, Inc. dba UNFI
Valu Merchandisers Company
Vantive US Healthcare LLC
Virexion Health Inc.
Walgreen Company
Walgreens
Walmart
WALMART INC
WE Soda Alkali LLC
Westminster Pharmaceuticals, LLC
WinCo Foods, LLC
World Perfumes Inc
Xtreme Personal Care Inc
Why It Matters
Sectors
HealthAgricultureFoodEnergyWaterConstructionMetals & MiningPlastics & RubberConsumer ProductsCore Chemicals
Downstream Uses
Appears in 140 drug and cosmetic product listings (FDA).
- •Sodium Bicarbonate
- •Omeprazole and Sodium Bicarbonate
- •Bath Bomb 2-pack (Lavender)
- •Bath Bomb 6-pack (Lemon)
- •Bath Bomb 6-pack (Orange)
- •Premixed saline packets
- •BM Sodium bicarbonate (Nat Bicarb)
- •Sinus Wash Packet
Show all 140
- •DE LA CRUZ Sodium Bicarbonate Antacid
- •Top Value Effervescent Pain Relief
- •Sodium Bicarbonate Antacid
- •Omeprazole, Sodium bicarbonate
- •Alka-Seltzer Gold
- •Quality Choice Effervescent Antacid and Pain Relief
- •Aller-Chord F
- •Zegerid
- •Walgreens Antacid Pain Relief Extra Strength
- •Xtreme Saline Rinse Mix
- •Sodium Bicarbonate 10 GR. (650 MG)
- •Bath Bomb 2-pack (Rose)
- •Bath Bomb 6-pack (Rose)
- •Nasal Rines SALT
- •Prismasol BGK2/0
- •Kroger Effervescent Antacid and Pain Relief
- •After Bite Kids
- •Medique Medi Seltzer
- •Equate NETI POT Sinus WASH
- •8.4% Sodium Bicarbonate
- •Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride with Lemon Flavor
- •Up and Up Antacid and Pain Relief
- •Rite Aid Antacid and Pain Relief
- •Prismasol B22GK4/0
- •Phoxillum BK4/2.5
- •Polyethylene Glycol-3350 AND Electrolytes
- •After Bite Advanced
- •Equate Comfort Flow Sinus wash
- •Ohtas ISAN Antacid
- •Elliotts B
- •Omeprazole/Bicarbonate
- •EcoDent Ultimate Essential Mouthcare Spicy-Cool Cinnamon
- •EcoDent Ultimate Essential Mouthcare Sparkling Clean Mint
- •Zegerid OTC
- •Bath Bomb 2-pack (Lemon)
- •Bath Bomb 2-pack (Eucalyptus)
- •Nasocalm Saline Rinse Mix Packets
- •Caring Mill Bug Bite Relief Wipes
- •Gavilyte-N
- •After Bite X Tech
- •Itch Eraser Sensitive
- •Good Sense Effervescent Antacid and Pain Relief
- •Pediatric 8.4% Sodium Bicarbonate
- •Alka-Seltzer Extra Strength
- •Alka-Seltzer Original
- •Leader Sinus Wash Saline Refill Packets
- •Leader Extra Strength Effervescent Antacid and Pain Reliever
- •Gurunanda Nasal Saline
- •Acid Reducer Powder
- •Quabic-300
- •Quabic-100
- •Prismasol BGK4/2.5
- •SinuCleanse
- •INON
- •7.5% Sodium Bicarbonate
- •GoLYTELY
- •Anti-Empacho
- •Sodium Bicarbonate 5 gr
- •Alka-Seltzer Heartburn
- •Best Choice Effervescent Antacid Pain Relief
- •CEO-TWO
- •Well at Walgreens
- •D-D Sudium Bicarbonate U.S.P. Bicarbonato DE SODA PURO
- •PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride
- •Phoxillum B22K4/0
- •Gavilyte G TM
- •Alka Seltzer Originial 1s Blister Pack
- •Rapidol Sodium Bicarbonate
- •CVS
- •Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - Unflavored
- •Alka-Seltzer
- •AHHH Bite Relief
- •Bath Bomb 6-pack (Peppermint)
- •Bath Bomb 6-pack (Eucalyptus)
- •Adrian Bicarbonato Sodium Bicarbonate USP-4 oz, 8 oz and 16 oz
- •Medis Sodium Bicarbonate
- •De La Cruz Desempacho
- •Prismasol BGK2/3.5
- •Prismasol BGK0/2.5
- •Prismasol BGK4/0/1.2
- •Care One Original Antacid and Pain Relief
- •Stomachin Antacid
- •GaviLyte - C TM
- •Equate Saline Packets
- •PEG-3350 and Electrolytes
- •WinCo Foods Effervescent Antacid and Pain Relief
- •Sal De Uvas Picot
- •Humco Sodium Bicarbonate
- •basic care omeprazole and sodium bicarbonate
- •Bath Bomb 2-pack (Peppermint)
- •Insect sting relief pad 01
- •Insect sting relief latex 01
- •All natural Saline Packets CareOne
- •Equate Effervescent Antacid and Pain Relief
- •Bromo Seltzer
- •Market Basket Effervescent Antacid and Pain Relief
- •Publix Fast Relief Effervescent
- •Alka-Seltzer Heartburn Relief Extra Strength
- •Alka-Seltzer Heartburn and Pain
- •Polyethylene Glycol 3350 and electrolytes with Lemon Flavor
- •Walgreens Effervescent Pain Relief
- •CVS Health Antacid and Pain Reliever
- •Sodium Bicarbonate 5 gr (325 mg)
- •equate omeprazole and sodium bicarbonate
- •Bath Bomb 2-pack (Orange)
- •E-Z-GAS II
- •Signature Care Effervescent Antacid and Pain Relief
- •Prismasol BK0/0/1.2
- •HEB Extra Strength Effervescent Antacid and Pain Relief
- •Meijer Effervescent Antacid and Pain Relief
- •Infant 4.2% Sodium Bicarbonate
- •Drug Mart Effervescent Pain Relief
- •Quality Choice Extra Strength Effervescent Antacid and Pain Relief
- •Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride with Orange Flavor
- •Sinus Wash Saline Refills Meijer
- •Bath Bomb 6-pack (Lavender)
- •Bestmade Natural Products Sodium Bicarbonate (Nat Bicarb)
- •DR. SANA Bicarbonato DE Sodio 4 Fl oz and 6 Floz
- •Sanar Baking Soda 8oz 100% pure
- •Arm and Hammer Baking Soda
- •Good Sense Omeprazole and Sodium Bicarbonate
- •TopCare Effervescent Antacid and Pain Relief
- •Effervescent Antacid and Pain Relief
- •Equaline Effervescent Antacid and Pain Relief
- •DG Health Effervescent Antacid and Pain Relief
- •N03 Exchem
- •Alka-Seltzer Heartburn Relief Lemon Lime
- •Polyethylene Glycol 3350 and electrolytes - Unflavored
- •Polyethylene Glycol 3350 and electrolyteswith Orange Flavor
- •Sodium Bicarbonate 10 gr
- •CVS Health Extra Strength Antacid and Pain Reliever
- •Omeprazole/Sodiium Bicarbonate
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
Active Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- Current shortage
Sodium Bicarbonate Injection
Shortage listed since March 1, 2017
Manufacturer reports: 2 unavailable, 2 available
Industrial Uses
Used in 20 sectors as 13 functional roles.
- •Abrasives in Mining (except Oil and Gas) and support activities (100%)Processing—incorporation into formulation, mixture, or reaction product
- •pH regulating agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •pH regulating agent in Food, beverage, and tobacco product manufacturing (100%)Use—non-incorporative activities
- •Catalyst in Petroleum Refineries (100%)Use—non-incorporative activities
- •Anti-freeze agent in Petrochemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •pH regulating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Intermediate in Agriculture, Forestry, Fishing and Hunting (95%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in Services (5%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in All Other Basic Inorganic Chemical Manufacturing (5%)Processing as a reactant
- •pH regulating agent in Pharmaceutical and Medicine Manufacturing (45%)Processing as a reactant
- •CBI in CBICBI
- •pH regulating agent in Wholesale and Retail TradeProcessing—incorporation into formulation, mixture, or reaction product
- •Surfactant (surface active agent) in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Foamant in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Pigment in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing) (0%)Processing—incorporation into formulation, mixture, or reaction product
- •Abrasives in Soap, Cleaning Compound, and Toilet Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Stabilizing agent in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing) (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Adsorbent in Other (1%)Use—non-incorporative activities
- •Adsorbent in Industrial Gas Manufacturing (6%)Use—non-incorporative activities
- •Adsorbent in Petroleum Refineries (93%)Use—non-incorporative activities
- •Laboratory chemicals in Not Known or Reasonably AscertainableNot Known or Reasonably Ascertainable
- •Catalyst in Agriculture, Forestry, Fishing and Hunting (100%)Processing as a reactant
- •pH regulating agent in UtilitiesProcessing—incorporation into article
- •Absorbent in UtilitiesUse—non-incorporative activities
- •pH regulating agent in Plastics Material and Resin Manufacturing (36%)Processing—repackaging
- •pH regulating agent in Custom Compounding of Purchased Resins (24%)Processing—incorporation into article
- •pH regulating agent in Plastics Product Manufacturing (40%)Processing—incorporation into article
Chemical Identity
CAS144-55-8
PubChem CID516892
DTXSIDDTXSID9021269
FormulaCHNaO3
Mol. Weight84.007 g/mol
SMILESC(=O)(O)[O-].[Na+]
Data Sources
- EPA CompTox (DSSTox) · DTXSID9021269Retrieved 2026-04-06
- PubChem · compound 516892Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Sodium bicarbonate (CAS 144-55-8) https://chemicalindependence.com/chemical/144-55-8/ EPA CompTox (DSSTox): DTXSID9021269. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021269 PubChem: 516892. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/516892 EPA Chemical Data Reporting: 144-55-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 144-55-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 283630 for CAS 144-55-8. Reporting year: 2024. https://usatrade.census.gov/