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Hydrocodone bitartrate

Drug ingredient

CAS 143-71-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 143-71-5
5 H₂O
US productionNot reported
Import value, 2024$103M
Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain
48 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Alvogen Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals of New York LLC
Asclemed USA, Inc.
Aurolife Pharma, LLC
AvPAK
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cambrex Charles City, Inc
Chattem Chemicals, Inc.
Cranbury Pharmaceuticals, LLC
Direct Rx
Elite Laboratories, Inc.
Epic Pharma, LLC
Eywa Pharma Inc
Genus Lifesciences Inc.
Golden State Medical Supply, Inc.
Granules Pharmaceuticals Inc.
Hikma Pharmaceuticals USA Inc.
KVK-Tech, Inc.
LETCO MEDICAL, LLC
Lupin Pharmaceuticals,Inc.
Medisca Inc.
Noramco, LLC
Novel Laboratories, Inc.
NuCare Pharmaceuticals, Inc.
PAI Holdings, LLC dba PAI Pharma
Pharma Source Direct, Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
Purdue Pharma LP
Quality Care Products, LLC
Redpharm Drug
RedPharm Drug, Inc
Rhodes Pharmaceuticals L.P.
Siegfried USA, LLC
SpecGx LLC
Spectrum Laboratory Products, Inc.
ST. MARY'S MEDICAL PARK PHARMACY
Strides Pharma Science Limited
Sun Pharmaceutical Industries, Inc.
Upsher-Smith Laboratories, LLC
Veranova, L.P.
XLCare Pharmaceuticals, Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 10 drug and cosmetic product listings (FDA).

  • •Hydrocodone Bitartrate and Acetaminophen
  • •Hydrocodone/APAP
  • •Hydrocodone Bitartrate and Homatropine Methylbromide
  • •Hydrocodone Bitartrate
  • •Hydromet
  • •Hydrocodone Bitartrate and Ibuprofen
  • •Hysingla ER
  • •Hycodan
Show all 10
  • •Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release
  • •Norco
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Homatropine Methylbromide and Hydrocodone Bitartrate Syrup

    Shortage listed since September 11, 2025

See all current drug shortages

Chemical Identity

CAS143-71-5
PubChem CID23724881
DTXSIDDTXSID40162277
FormulaC44H64N2O23
Mol. Weight989 g/mol
SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O.O.O.O.O

Data Sources

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Brief citations

Hydrocodone bitartrate (CAS 143-71-5) https://chemicalindependence.com/chemical/143-71-5/ PubChem: 23724881. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/23724881 FDA National Drug Code directory: CAS 143-71-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 143-71-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293911 for CAS 143-71-5. Reporting year: 2024. https://usatrade.census.gov/