Entecavir

Drug ingredient

CAS 142217-69-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

24 FDA-registered drug labelers

American Health Packaging

Amneal Pharmaceuticals Co. (I) Pvt. Ltd.

Amneal Pharmaceuticals LLC

Aurobindo Pharma Limited

AvKARE

Carlsbad Technology, Inc.

Cipla Ltd.

Cipla USA Inc.

E.R. Squibb & Sons, L.L.C.

EPIC PHARMA, LLC

Golden State Medical Supply, Inc.

Hetero Drugs Limited

NorthStar RxLLC

Patheon Inc.

ScinoPharm Taiwan Ltd.

Siegfried Evionnaz SA

SK BIOTEK IRELAND LIMITED

Wisdom Pharmaceutical Co.,Ltd

Yaopharma Co., Ltd.

Yung Shin Pharmaceutical Ind. Co., Ltd.

Zhejiang Ausun Pharmaceutical Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Entecavir
•Baraclude

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS142217-69-4

PubChem CID135398508

DTXSIDDTXSID4046446

FormulaC12H15N5O3

Mol. Weight277.28 g/mol

SMILESC=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N

Data Sources

PubChem · compound 135398508Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Entecavir (CAS 142217-69-4) https://chemicalindependence.com/chemical/142217-69-4/ PubChem: 135398508. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135398508 FDA National Drug Code directory: CAS 142217-69-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 142217-69-4. Reporting year: 2024. https://usatrade.census.gov/