Osimertinib

Drug ingredient

CAS 1421373-65-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1421373-65-0
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
3 FDA-registered drug labelers
AstraZeneca AB
AstraZeneca Pharmaceuticals LP
DOTTIKON EXCLUSIVE SYNTHESIS AG

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Tagrisso
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$7.20/gAaron Chemicals LLC
CountryHong Kong
Pack$720.00 / 100 g
Purity99%
Vendors25 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS1421373-65-0
PubChem CID71496458
DTXSIDDTXSID501025961
FormulaC28H33N7O2
Mol. Weight499.6 g/mol
SMILESCN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

Data Sources

Brief citations

Osimertinib (CAS 1421373-65-0) https://chemicalindependence.com/chemical/1421373-65-0/ PubChem: 71496458. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71496458 FDA National Drug Code directory: CAS 1421373-65-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 1421373-65-0. Reporting year: 2024. https://usatrade.census.gov/