Tenofovir alafenamide fumarate

Drug ingredient

CAS 1392275-56-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

15 FDA-registered drug labelers

A-S Medication Solutions

Aurobindo Pharma Limited

Cipla Ltd.

Esteve Quimica SA

Gilead Sciences, Inc.

HETERO LABS LIMITED

Honour Lab Limited

Macleods Pharmaceuticals Limited

Matrix Pharmacorp Private Limited

Patheon Inc.

Rottendorf Pharma GmbH

Shanghai Desano Chemical Pharmaceutical Co., Ltd.

Takeda GmbH

Wuhan Calmland Pharmaceuticals Co., Ltd.

YiChang HEC ChangJiang Pharmaceuical Co.,Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Genvoya
•Biktarvy
•Descovy
•Odefsey
•Vemlidy

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1392275-56-7

PubChem CID71492247

DTXSIDDTXSID401027740

FormulaC46H62N12O14P2

Mol. Weight1069 g/mol

SMILESCC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O

Data Sources

PubChem · compound 71492247Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tenofovir alafenamide fumarate (CAS 1392275-56-7) https://chemicalindependence.com/chemical/1392275-56-7/ PubChem: 71492247. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71492247 FDA National Drug Code directory: CAS 1392275-56-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 1392275-56-7. Reporting year: 2024. https://usatrade.census.gov/