pemetrexed acid

Drug ingredient

CAS 137281-39-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

1 FDA-registered drug labeler

TAPI Czech Industries s.r.o.

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$2.46/gAaron Chemicals LLC

CountryHong Kong

Pack$246.00 / 100 g

Purity98%

Vendors15 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

14 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$2.49	100 g	98%
MedChemExpress MCE	Sweden	$4.32	100 g	—
BLD Pharmatech Co., Limited	United States	$4.80	100 g	98%
BLD Pharmatech Ltd.	China	$4.80	100 g	98%
Ambeed, Inc.	United States	$4.80	100 g	98%
Combi-Blocks, Inc.	United States	$4.80	100 g	98%
A2B Chem LLC	United States	$5.12	25 g	98%
AA BLOCKS	United States	$5.40	100 g	98%
Fluorochem EU	Germany	$6.78	5 g	98%
Angene International Limited	United States	$6.80	10 g	98%
BLD Pharmatech GmbH	Germany	$7.20	25 g	98%
Synthonix	United States	$12.00	5 g	98%
AstaTech, Inc	United States	$38.80	5 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS137281-39-1

PubChem CID135405776

DTXSIDDTXSID80430861

FormulaC15H14N4O3

Mol. Weight298.3 g/mol

SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)O

Data Sources

PubChem · compound 135405776Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

pemetrexed acid (CAS 137281-39-1) https://chemicalindependence.com/chemical/137281-39-1/ PubChem: 135405776. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135405776 FDA National Drug Code directory: CAS 137281-39-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 137281-39-1. Reporting year: 2024. https://usatrade.census.gov/