Pemetrexed

Drug ingredient

CAS 137281-23-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

5 FDA-registered drug labelers

Avyxa Pharma, LLC

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

MSN Laboratories Private Limited

ScinoPharm Taiwan Ltd.

Teva Czech Industries s.r.o

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Axtle
•Pemetrexed Dipotassium

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Pemetrexed Disodium Injection
Shortage listed since October 10, 2025
to be discontinued
Pemetrexed Ditromethamine Injection
Shortage listed since July 17, 2025

See all current drug shortages

Chemical Identity

CAS137281-23-3

PubChem CID135410875

DTXSIDDTXSID2048329

FormulaC20H21N5O6

Mol. Weight427.4 g/mol

SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O

Data Sources

PubChem · compound 135410875Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Pemetrexed (CAS 137281-23-3) https://chemicalindependence.com/chemical/137281-23-3/ PubChem: 135410875. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135410875 FDA National Drug Code directory: CAS 137281-23-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 137281-23-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293359 for CAS 137281-23-3. Reporting year: 2024. https://usatrade.census.gov/