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Duloxetine hydrochloride

Drug ingredient

CAS 136434-34-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 136434-34-9
1 HCl
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
55 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
Ajanta Pharma USA Inc.
Alembic Pharmaceuticals Limited
American Health Packaging
Aphena Pharma Solutions - Tennessee, LLC
Ascend Laboratories, LLC
Asclemed USA, Inc.
Aurobindo Pharma Limited
BluePoint Laboratories
Breckenridge Pharmaceutical, Inc.
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Coupler LLC
Direct_Rx
Dr.Reddy's Laboratories Limited
Eli Lilly and Company
Evonik Corporation
Golden State Medical Supply, Inc.
Hetero Drugs Limited
Inventia Healthcare Limited.
Jubilant Biosys limited
Lilly del Caribe, Inc.
Lupin Pharmaceuticals, Inc.
Macleods Pharmaceuticals Limited
Major Pharmaceuticals
MARKSANS PHARMA LIMITED
MSN Laboratories Private Limited
NCS HealthCare of KY, LLC dba Vangard Labs
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
PD-Rx Pharmaceuticals, Inc.
Preferred Phamaceuticals Inc.
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
Qingdao BAHEAL Pharmaceutical Co., Ltd.
Quality Care Products LLC
Quallent Pharmaceuticals Health LLC
R.L.Fine Chem Private Limited
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
SCI PHARMTECH, INC.
Signa S.A. de C.V.
Solco Healthcare US, LLC
ST. MARY'S MEDICAL PARK PHARMACY
SUN PHARMACEUTICAL INDUSTRIES, INC.
Towa Pharmaceutical Europe, S.L.
Uquifa Spain
Yaopharma Co., Ltd.
YiChang HEC ChangJiang Pharmaceutical Co.,Ltd.
Zydus Lifesciences Limited

Why It Matters

Sectors
Health
Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

  • •Duloxetine Delayed-Release
  • •Duloxetine
  • •Duloxetine D/R
  • •Drizalma Sprinkle
  • •Duloxetine Hydrochloride
  • •Duloxetine HCL DR
  • •Cymbalta
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS136434-34-9
PubChem CID60834
DTXSIDDTXSID9046443
FormulaC18H20ClNOS
Mol. Weight333.9 g/mol
SMILESCNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl

Data Sources

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Brief citations

Duloxetine hydrochloride (CAS 136434-34-9) https://chemicalindependence.com/chemical/136434-34-9/ PubChem: 60834. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/60834 FDA National Drug Code directory: CAS 136434-34-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 136434-34-9. Reporting year: 2024. https://usatrade.census.gov/