Palonosetron hydrochloride

Drug ingredient

CAS 135729-62-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 135729-62-3 — 1 HCl

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

29 FDA-registered drug labelers

Apotex Corp.

Aurobindo Pharma Limited

Avenacy, Inc.

Avyxa Pharma, LLC

Baxter Healthcare Corporation

BluePoint Laboratories

Catalent Pharma Solutions, LLC

Cipla Ltd.

Cipla USA Inc.

Dr.Reddy's Laboratories Limited

Emcure Pharmaceuticals Limited

Eugia US LLC

Fresenius Kabi USA, LLC

HAS Healthcare Advanced Synthesis SA

Helsinn Therapeutics (U.S.), Inc.

Meitheal Pharmaceuticals Inc.

MSN Laboratories Private Limited

Mylan Institutional LLC

NorthStar Rx LLC

Qilu Pharmaceutical Co. Ltd.

Rolabo Outsourcing S.L.

Sagent Pharmaceuticals

Sandoz Inc

TAPI Czech Industries s.r.o.

Teva Czech Industries s.r.o

Teva Parenteral Medicines, Inc.

TYCHE INDUSTRIES LIMITED

USV Private Limited

Wavelength Enterprises LTD

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Palonosetron
•posfrea
•Palonosetron Hydrochloride
•Akynzeo

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Palonosetron Hydrochloride Injection
Shortage listed since November 14, 2025

See all current drug shortages

Chemical Identity

CAS135729-62-3

PubChem CID6918303

DTXSIDDTXSID8046610

FormulaC19H25ClN2O

Mol. Weight332.9 g/mol

SMILESC1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5.Cl

Data Sources

PubChem · compound 6918303Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Palonosetron hydrochloride (CAS 135729-62-3) https://chemicalindependence.com/chemical/135729-62-3/ PubChem: 6918303. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6918303 FDA National Drug Code directory: CAS 135729-62-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 135729-62-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293379 for CAS 135729-62-3. Reporting year: 2024. https://usatrade.census.gov/