Palonosetron

Drug ingredient

CAS 135729-56-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

1 FDA-registered drug labeler

Helsinn Therapeutics (U.S.), Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Akynzeo

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Palonosetron Hydrochloride Injection
Shortage listed since November 14, 2025

See all current drug shortages

Chemical Identity

CAS135729-56-5

PubChem CID6337614

DTXSIDDTXSID5048342

FormulaC19H24N2O

Mol. Weight296.4 g/mol

SMILESC1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5

Data Sources

PubChem · compound 6337614Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Palonosetron (CAS 135729-56-5) https://chemicalindependence.com/chemical/135729-56-5/ PubChem: 6337614. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6337614 FDA National Drug Code directory: CAS 135729-56-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 135729-56-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293379 for CAS 135729-56-5. Reporting year: 2024. https://usatrade.census.gov/