avacopan

Drug ingredient

CAS 1346623-17-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.3B

Top sourceChina 32%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293339 · basket

These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland

Taiwan
Ukraine
Sweden
Argentina
Canada
Finland
Malta
Israel
Netherlands
Denmark
United Arab Emirates
Mexico
Brunei
Slovakia
Australia
South Africa
Poland
Latvia
Lithuania
Estonia
Slovenia
Czech Republic
Croatia
Hong Kong

8 FDA-registered drug labelers

ChemoCentryx, Inc.

HETERO LABS LIMITED

Hovione LLC

Lonza AG

Maithri Drugs Private Limited

MW ENCAP LIMITED

NURAY CHEMICALS PRIVATE LIMITED

Patheon Pharmaceuticals Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Tavneos

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1346623-17-3

PubChem CID49841217

DTXSIDDTXSID701102660

FormulaC33H35F4N3O2

Mol. Weight581.6 g/mol

SMILESCC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F

Data Sources

PubChem · compound 49841217Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

avacopan (CAS 1346623-17-3) https://chemicalindependence.com/chemical/1346623-17-3/ PubChem: 49841217. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/49841217 FDA National Drug Code directory: CAS 1346623-17-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293339 for CAS 1346623-17-3. Reporting year: 2024. https://usatrade.census.gov/