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Naldemedine tosylate

Drug ingredient

CAS 1345728-04-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1345728-04-2
US productionNot reported
Import value, 2024$50M
Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark
2 FDA-registered drug labelers
BioDelivery Sciences International Inc
Shionogi Pharma Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Symproic
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS1345728-04-2
PubChem CID56837137
DTXSIDDTXSID10158809
FormulaC39H42N4O9S
Mol. Weight742.8 g/mol
SMILESCC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C1=NC(=NO1)C2=CC=CC=C2)NC(=O)C3=C(C4C56CCN(C(C5(C3)O)CC7=C6C(=C(C=C7)O)O4)CC8CC8)O

Data Sources

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Brief citations

Naldemedine tosylate (CAS 1345728-04-2) https://chemicalindependence.com/chemical/1345728-04-2/ PubChem: 56837137. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/56837137 FDA National Drug Code directory: CAS 1345728-04-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293919 for CAS 1345728-04-2. Reporting year: 2024. https://usatrade.census.gov/