Tolcapone

Drug ingredient

CAS 134308-13-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$175M

Top sourceIndia 48%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291479 · basket

These shares come from HS customs code 291479, which covers 95 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 48%IndiaCN 20%ChinaMX 19%MexicoDE 10%GermanyFI 2%Finland

Ukraine
Japan
Australia
Netherlands
South Korea
Canada
Switzerland
Russia
Poland
Italy
United Kingdom
Spain
Taiwan
Grenada

6 FDA-registered drug labelers

Anthem Biosciences Limited

Bausch Health US LLC

COHANCE LIFESCIENCES LIMITED

Ingenus Pharmaceuticals, LLC

Oceanside Pharmaceuticals

Piramal Pharma Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Tolcapone
•Tasmar

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$29.44/gAaron Chemicals LLC

CountryHong Kong

Pack$736.00 / 25 g

Purity99%

Vendors23 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

22 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$29.64	25 g	99%
Combi-Blocks, Inc.	United States	$78.40	25 g	98%
A2B Chem LLC	United States	$82.84	25 g	98%
AA BLOCKS	United States	$87.44	25 g	98%
Fulfilled by Molport	Latvia	$170.00	100 mg	99%
Ambeed, Inc.	United States	$195.00	1 g	98%
TargetMol Chemicals	China → United States	$632.00	500 mg	99.89%
AK Scientific Specialized	United States	$702.00	1 g	95%
Molnova	China	$850.00	200 mg	99%
TargetMol Chemicals EU	Austria	$945.00	200 mg	99.89%
AK Scientific, Inc.	United States	$983.00	1 g	97%
Angene International Limited	United States	$1543.00	1 g	97%
MedChemExpress MCE	Sweden	$2057.00	100 mg	99.91%
Apexbio Technology LLC	United States	$2400.00	50 mg	99.42%
Angene	China → Hong Kong	$2500.00	30 mg	99%
Sigma-Aldrich (Rush Stock)	Germany	$2610.40	200 mg	—
Sigma-Aldrich	Germany	$2610.40	200 mg	—
Axon Medchem	Netherlands	$3360.00	50 mg	99%
AstaTech (2 weeks)	United States	$4636.00	250 mg	95%
Cayman Europe	Estonia	$5759.60	100 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
MedKoo Biosciences, Inc	United States	$8000.00	100 mg	98%

Chemical Identity

CAS134308-13-7

PubChem CID4659569

DTXSIDDTXSID3023685

FormulaC14H11NO5

Mol. Weight273.24 g/mol

SMILESCC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]

Data Sources

PubChem · compound 4659569Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tolcapone (CAS 134308-13-7) https://chemicalindependence.com/chemical/134308-13-7/ PubChem: 4659569. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4659569 FDA National Drug Code directory: CAS 134308-13-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291479 for CAS 134308-13-7. Reporting year: 2024. https://usatrade.census.gov/