Hydroxocobalamin

Drug ingredientActive Shortage

CAS 13422-51-0

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 13422-51-0 — 1 Co³⁺ · 1 OH⁻

US productionNot reported

Import value, 2024$70M

Top sourceChina 85%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293626 · narrow

These shares come from HS customs code 293626, which covers 4 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 85%ChinaES 9%SpainIN 3%IndiaIT 2%ItalyPT 1%Portugal

Mexico
Germany
Colombia
Canada
Poland
United Kingdom
South Korea
Turkey
Estonia

8 FDA-registered drug labelers

BTG INTERNATIONAL INC.

EUROAPI FRANCE

Interquim, S.A. de C.V.

NURAY CHEMICALS PRIVATE LIMITED

Professional Compounding Centers of America dba PCCA

Sanofi Winthrop Industrie

Spectrum Laboratory Products, Inc.

Supriya Lifescience Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Cyanokit

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Hydroxocobalamin Injection
Shortage listed since November 4, 2024
Manufacturer reports: 1 unavailable, 1 limited

See all current drug shortages

Chemical Identity

CAS13422-51-0

PubChem CID44475014

DTXSIDDTXSID60897433

FormulaC62H89CoN13O15P

Mol. Weight1346.4 g/mol

SMILESCC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[OH-].[Co+3]

Data Sources

PubChem · compound 44475014Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Hydroxocobalamin (CAS 13422-51-0) https://chemicalindependence.com/chemical/13422-51-0/ PubChem: 44475014. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/44475014 EPA TSCA Inventory: CAS 13422-51-0. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 13422-51-0. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293626 for CAS 13422-51-0. Reporting year: 2024. https://usatrade.census.gov/