Insulin lispro

Drug ingredient

CAS 133107-64-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$16.4B

Top sourceIreland 94%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293719 · basket

These shares come from HS customs code 293719, which covers 53 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 94%IrelandAR 4%ArgentinaCN 1%ChinaDK 1%Denmark

Switzerland
Sweden
India
Spain
Israel
Austria
Belgium
Netherlands
Italy
Hong Kong
Brazil
United Kingdom
Germany
Canada
Australia
Japan
New Zealand
Latvia
South Korea
Taiwan
Estonia
Uruguay

7 FDA-registered drug labelers

A-S Medication Solutions

Eli Lilly and Company

Eli Lilly Italia SPA

Lilly del Caribe, Inc.

Lilly France

REMEDYREPACK INC.

Sanofi-Aventis U.S. LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 16 drug and cosmetic product listings (FDA).

•Humalog
•Lyumjev
•Lyumjev KwikPen
•Insulin Lispro KwikPen
•Humalog KwikPen
•Insulin Lispro
•Admelog
•Lyumjev Tempo Pen

Show all 16

•Lyumjev Junior KwikPen
•Humalog Mix75/25
•Humalog Tempo Pen
•Humalog Mix75/25 KwikPen
•Humalog Junior KwikPen
•Insulin Lispro Junior KwikPen
•Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen
•Humalog Mix50/50 KwikPen

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Insulin Lispro-aabc Injection
Shortage listed since October 24, 2025
to be discontinued
Insulin Lispro Injection
Shortage listed since October 24, 2025

See all current drug shortages

Chemical Identity

CAS133107-64-9

PubChem CID16132438

DTXSIDDTXSID90157956

FormulaC257H389N65O77S6

Mol. Weight5814 g/mol

SMILESCCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N

Data Sources

PubChem · compound 16132438Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Insulin lispro (CAS 133107-64-9) https://chemicalindependence.com/chemical/133107-64-9/ PubChem: 16132438. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16132438 FDA National Drug Code directory: CAS 133107-64-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 133107-64-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293719 for CAS 133107-64-9. Reporting year: 2024. https://usatrade.census.gov/