Trichlormethiazide

Drug ingredient

CAS 133-67-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$2.0B

Top sourceIreland 63%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland

Portugal
Spain
Italy
Austria
Israel
Hungary
Canada
South Korea
Netherlands
Finland
Poland
Indonesia
Ukraine
Mexico
South Africa
Croatia
Greece
Taiwan
Hong Kong

2 FDA-registered drug labelers

Derivados Quimicos SAU

Medisca Inc.

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$3.91/gAaron Chemicals LLC

CountryHong Kong

Pack$391.00 / 100 g

Purity98%

Vendors20 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

19 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$4.19	100 g	98%
A2B Chem LLC	United States	$4.80	25 g	98%
Combi-Blocks, Inc.	United States	$4.80	25 g	98%
AA BLOCKS	United States	$6.28	25 g	98%
Ambeed, Inc.	United States	$8.00	5 g	98%
AK Scientific, Inc.	United States	$11.00	5 g	97%
MedChemExpress MCE	Sweden	$19.96	10 g	98.54%
TargetMol Chemicals	China → United States	$24.00	2 g	99.54%
Angene International Limited	United States	$24.00	5 g	97%
Cayman Europe	Estonia	$26.66	10 g	98%
Apexbio Technology LLC	United States	$28.60	5 g	98.91%
TargetMol Chemicals EU	Austria	$33.00	1 g	99.54%
Molnova	China	$48.00	1 g	99%
MedKoo Biosciences, Inc	United States	$65.00	10 g	98%
AstaTech (2 weeks)	United States	$65.20	10 g	98%
Labotest KG	Germany	$453.00	1000 mg	90%
Sigma-Aldrich (Rush Stock)	Germany	$2250.55	200 mg	—
Sigma-Aldrich	Germany	$2250.55	200 mg	—
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS133-67-5

PubChem CID5560

DTXSIDDTXSID7023699

FormulaC8H8Cl3N3O4S2

Mol. Weight380.7 g/mol

SMILESC1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl

Data Sources

PubChem · compound 5560Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Trichlormethiazide (CAS 133-67-5) https://chemicalindependence.com/chemical/133-67-5/ PubChem: 5560. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5560 EPA TSCA Inventory: CAS 133-67-5. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293590 for CAS 133-67-5. Reporting year: 2024. https://usatrade.census.gov/