rifampin

Drug ingredientActive Shortage

CAS 13292-46-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$546M

Top sourceItaly 41%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294190 · basket

These shares come from HS customs code 294190, which covers 90 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 24%ChinaDK 9%DenmarkHR 6%CroatiaIN 6%India

United Kingdom
Slovakia
Slovenia
Mexico
Canada
Germany
Belgium
Japan
Switzerland
Netherlands
Czech Republic
Uruguay
South Korea
Hong Kong
Portugal
Australia

24 FDA-registered drug labelers

A-S Medication Solutions

American Health Packaging

Asclemed USA, Inc.

Bryant Ranch Prepack

Chartwell RX, LLC

CKD BIO Corp. Ansan Factory

CKD Bio Corporation

Coupler LLC

DARMERICA, LLC

EPIC PHARMA, LLC

EUROAPI Italy SRL

Fresenius Kabi USA, LLC

Hikma Pharmaceuticals USA Inc.

Kalchem International inc

Luohe Chief Pharmaceutical Co., Ltd.

LUPIN LIMITED

Lupin Pharmaceuticals, Inc.

Major Pharmaceuticals

MEDISCA Inc.

Mylan Institutional LLC

OLON ACTIVE PHARMACEUTICAL INGREDIENTS INDIA PRIVATE LIMITED

Olon SpA

PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS

Sanofi-Aventis U.S. LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Rifampin
•Rifadin IV

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Rifampin Injection
Shortage listed since February 17, 2021
Manufacturer reports: 1 unavailable, 1 available
Current shortage
Rifampin Capsule
Shortage listed since December 22, 2021
Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS13292-46-1

PubChem CID135398735

DTXSIDDTXSID6021244

FormulaC43H58N4O12

Mol. Weight822.9 g/mol

SMILESCC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C

Data Sources

PubChem · compound 135398735Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

rifampin (CAS 13292-46-1) https://chemicalindependence.com/chemical/13292-46-1/ PubChem: 135398735. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135398735 FDA National Drug Code directory: CAS 13292-46-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 13292-46-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 294190 for CAS 13292-46-1. Reporting year: 2024. https://usatrade.census.gov/