Arsenic oxide (As2O3)
Drug ingredientCAS 1327-53-3
This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$75M
Import volume5.1M lb
Top sourceChina 30%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 281129 · basket
EPA reports by year
- 2023
- US production Confidential · Imports 5.1M lb
- 2019
- US production Confidential · Imports Confidential
These shares come from HS customs code 281129, which covers 18 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 30%ChinaAT 23%AustriaPL 9%PolandCA 8%CanadaCZ 8%Czech Republic
- Italy
- Romania
- Malaysia
- India
- Netherlands
- Ukraine
- Denmark
- Singapore
- Switzerland
- Morocco
- United Kingdom
EPA-registered manufacturers (5)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Rio Tinto Plc · GB United Kingdom
Shell Plc · GB United Kingdom
Rio Tinto America
Shell Catalyst & Technologies
Shell Catalysts & Technologies
EPA-registered importers (4)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Umicore Sa · BE Belgium
Arxada
Koppers
Umicore Usa
Why It Matters
Sectors
HealthAgricultureConstructionMetals & MiningCore Chemicals
Downstream Uses
Appears in 531 drug and cosmetic product listings (FDA).
- •Cold and Flu Relief
- •Mens Sports Formula
- •Neuro-Pro T007
- •WHP Colds and Cough
- •WHP Sleeplessness
- •Kids Relief
- •Bestmade Natural Products BM39
- •Bestmade Natural Products BM121
Show all 531
- •GUNA HAY Fever Relief
- •Psoriasis HP
- •Sinus HP
- •Weed Grass Antigen
- •TREE Antigen
- •Allergy Pollen
- •Mold Antigen
- •FCS CP
- •Perfect Sleep
- •Upper Respiratory Support
- •Governing Vessel Conception Vessel Meridian Opener
- •Habit
- •Adrenal Support
- •Energy Catalyst
- •AnXious
- •Allerpoll HP
- •Edema HP
- •Mold Mix Antigens
- •Epiforce E-HP
- •Neurotox
- •Metalogin
- •Vitalizer
- •Anxiety
- •V HP
- •Anxiety HP
- •Chemstat
- •Dermapar
- •Metalstat
- •Arsenicum album
- •Sciatic AIDE
- •Post-Vaccination
- •Cold - Sinus
- •Eczema - Skin Care
- •Eye Care
- •Fever - Infection
- •Menstrual - PMS
- •Tobacco Withdrawal
- •Hemorrhoids
- •Diabase
- •Rashes-Hives
- •Distress-Mood-Sadness
- •Fungal
- •Acne - Cystic Acne
- •Exhaustion
- •Hay Fever
- •Allergies
- •Sleep Aid
- •Allergy Relief Indoor and Outdoor
- •D-40
- •D-137
- •D-154
- •Supren
- •Allerhale
- •Total FLU CLD 1
- •Anti-Inflammation Drops 2005
- •Psorinum Miasm Drops 2054
- •Rheuma Pain II Drops 2058
- •Metex 6013
- •Travel Immunization Detox 6033
- •Mercurius Combination 9233
- •Secale Combination 9244
- •Pollinosis Combination 9261
- •Nematodes Nosode Combination 9404
- •Parasite Nosode Combination 9405
- •F27 MVON
- •Arsenic Trioxide
- •Viral HP
- •Stress
- •Bestmade Natural Products BM8
- •Bestmade Natural Products BM26
- •Bestmade Natural Products Hair Support
- •Bestmade Natural Products Restful Legs Support
- •GERM HP
- •Mood
- •FCS HP
- •Lung Large Intestine Meridian Opener
- •Circulation
- •Hers Plus
- •BORR PLUS
- •Virimmune
- •Skin Infections
- •PTS/Stress Remedy
- •Herz Plus
- •Immune Support
- •Heart Small Intestine Meridian Opener
- •Pneumo HP
- •ASP
- •Allergen II
- •Ars Alb
- •Colopar
- •Thymupar
- •Gastrotone
- •Pyostat
- •Histastat Pollen
- •Vermiclear
- •B HP
- •Immunopar
- •Mitochondria PRO
- •Neurotransmitter Pro
- •Lymphastat V
- •Multi Food Antigens
- •Jointox BB
- •Sniffles
- •Tummy Upset
- •Blues - Mood - Emotions
- •Feminine Comfort
- •Indigestion-Gas
- •Inflammation
- •Pollen-Weeds
- •Prime
- •Fungus Fighter
- •Just In Case
- •Hyperactivity-Mental Focus
- •Immu-n Waker
- •Cold - Cough
- •Gas-Indigestion
- •Neuro-Care
- •BronCare
- •Para-Si
- •Skin Irritations and Itch Relief
- •Sciatic Nerve Formula
- •D-54
- •ImmunoBooster
- •Party Relief
- •Water
- •Insecticides/Pest/Food Additives Detox
- •Asthma Drops 2010
- •Angina Drops 2083
- •Carcinosin Miasm Drops 2142
- •Stomach Saver
- •Calm Anxiety and Stress
- •Sleep Well T012
- •Respiro-Pro T016
- •Homeoplex G
- •Energy Complex
- •Bestmade Natural Products BM125
- •Bestmade Natural Products BM144
- •Bestmade Natural Products BM150
- •Bestmade Natural Products BM212
- •Weight Management HP
- •Nausea CP
- •Vermasode
- •Bio Glyoxal Phase
- •Breathe
- •HerX
- •Stomach Spleen Meridian Opener
- •Petrochemical Detox
- •VACC HC
- •Allerforce
- •Cough HP
- •Anti Hive
- •Additox
- •Renotox
- •Epiforce P-HP
- •Septaforce
- •Grain and Seed Antigens
- •Gastropanpar
- •Free Radistat
- •Lymphastat B
- •Flu-Cold
- •Bowel-Digestive Care
- •Airway Ease
- •Dust-Mold-Dander
- •Hair-Scalp
- •Hangover Help
- •Rheumatic-Joint Care
- •Ear Care
- •Panic Ease
- •Cataracc
- •Influenza
- •Homeopathic Calm Drops
- •D-97
- •D-136
- •Pain Formula II Drops 2090
- •Pulsatilla Combination 9238
- •F04 FR-TRST
- •Arsenicum Oxydatum
- •AmazaPet
- •Restless Legs
- •Arsenicum Album 30c
- •Psoriasis
- •Bestmade Natural Products BM118
- •Sciatic Formula
- •Diarrhea Formula
- •Thymus Sarcode
- •GUNA-Dermo
- •GUNA-Allergy T
- •Asthma Therapy
- •Arsenicum Album 200C
- •Dandi HP
- •Congestion HP
- •Swelling HP
- •BURN Relief
- •Hives
- •Pain and Fatigue Relief
- •Fibromyalgia Support
- •Chemtox
- •Addiclenz
- •Oral Health
- •Metox
- •Nightshade Antigen
- •Pneumotox
- •B Force HP
- •Balanceforce V
- •LD Force
- •Relaxatone
- •Mold Antigens
- •Bio-Immune
- •Psora Miasm
- •Hypercalm-Mental Focus
- •Cold Hands - Feet
- •Menopause
- •Sciatica-Nerve Care
- •Flu Care
- •Edema - Fluid Retention
- •Headache
- •Incontinence
- •Female Femroids
- •Connec-T
- •Herpes Sores
- •Dairy-Grain-Nightshade
- •Headache-Migraine
- •Restless Leg Symptom Relief
- •D-65
- •D-101
- •D-105
- •D134
- •D-155
- •Sleep Tight
- •Mytox 6021
- •Causticum Combination 9253
- •B11 Injurotox
- •B20 Acute Rescue
- •F03 FR-RLS
- •Lung-Resp
- •Para-BN
- •Mucus-Clear Flu Relief
- •Supreme
- •Arsenicum Album 30X
- •Bactoflam
- •Bestmade Natural Products BM193
- •Prostate Liquescence
- •BM Arsenicum Album
- •Arsenic ALB
- •COLD/FLU HP
- •Multiple Miasm
- •HP Axis
- •EHRL Plus
- •Anxiety II HP
- •Insomnia HP
- •Cystoforce
- •B Force
- •Stomaplex
- •Lactistat
- •Pulmopar
- •Additivestat
- •Mast Cell Pro
- •Lymphastat
- •MBM 9 Spleen/Pancreas
- •Restful Legs PM
- •Jet Lag
- •Teeth-Gums
- •Snore-Soothe
- •Prime of Life
- •G-Inflamm
- •Intestia
- •Fear
- •V-Fem Care
- •Digestive Care
- •Joint Care
- •Constitutional Enhancer
- •D-38
- •D-49
- •D-71
- •Ferrodonna
- •DigestivEase
- •Fungisode
- •Hendel Indigestion and Bloating
- •Ulcer Drops 2094
- •Toxagent Detox 6035
- •Arsenicum album 7104
- •Leptandra Combination 9230
- •Arsenicum Combination 9251
- •Fungus Nosode Combination 9401
- •Tapeworm Nosode Combination 9403
- •B01 Acute Rescue
- •Vac-Chord
- •WHP Stomach Disorders
- •Real Relief
- •H.M.D.
- •FLU
- •Parasode
- •Bestmade Natural Products BM53
- •Homeostop
- •Metex
- •Mytox
- •Enviro Detox Formula
- •Eczema HP
- •Animal Antigen
- •Germasode
- •Imucode
- •Gastrozen
- •Nasal Decongestant
- •BART PLUS
- •DysBio Plus
- •Pneumoplex
- •Colic
- •Weed and Grass Antigen
- •Animal Antigens
- •Respiforce A
- •Respiforce F-HP
- •Respiforce A-HP
- •Allergen I
- •Neuropar
- •Spleenpar
- •Gastropar
- •Industristat
- •Dust Mix Antigens
- •Weed Grass Antigens
- •Smogstat
- •Histastat Food
- •Focus Spectrum HP
- •Urinary HP
- •Bladdertone
- •Jointstat BB
- •Tree Antigens
- •Arsenicum album 30
- •Fatigue Fighter
- •Panic Button
- •Vitality
- •I-Sleep
- •Vitiligo
- •CardCare
- •D-23
- •D-43
- •D-69
- •Ailgeno
- •DiarrheaCalm
- •Syphilinum Miasm Drops 2064
- •Endotoxin Terrain Drops 2143
- •Cough Tonic 2995
- •Thymus Drops 5027
- •Opsin I 6014
- •Opsin II 6015
- •Food Poisoning Detox 6023
- •POP Detox 6045
- •F02 ANGR-FLX
- •F09 LTGO
- •Category III
- •Phase 6 Drops
- •Sleep HP
- •Virex
- •Bestmade Natural Products BM234
- •Bestmade Natural Products BM252
- •Cardiovascular Formula
- •Natural Relief Cold and Flu Plus Zinc
- •Allergy HP
- •FLU HP
- •Dust Mix Antigen
- •Stress / Fatigue
- •Cough Syrup
- •Biological Complex III
- •Pollutox
- •Pest and Dustmite Formula
- •Diathesis II
- •Free Radical
- •Bio Chem Detox
- •Sinusforce
- •LD Force HP
- •Lipotox
- •Vertitone
- •Cough - Airway
- •Hives-Rashes
- •Rosacea
- •Shing-V
- •Stage Fright-Fear
- •Oral Care-Gingivitis
- •Sciatica-Back Care
- •Candid-Y
- •Edema
- •D-5
- •N-23
- •ER 911
- •UNDA 20
- •Pyrogenium PLEX
- •ChemDetox
- •Pain Formula Drops 2046
- •Rib Cage Pain Drops 2056
- •Sleep Disorder Drops 2152
- •Lymph/Spleen/Mammary Drops 5014
- •Echinacea Combination 9222
- •R20 Testogen
- •Joette Calabrese Survivalist Kit
- •Emvita 6
- •NeuropathEase
- •Well-Ex
- •Mucus Clear Cough and Cold Relief
- •Bac
- •Bestmade Natural Products BM111
- •Bestmade Natural Products Arsenicum Album
- •Food Poisoning Detox
- •ANTI AGE VEIN
- •GUNA-PMS
- •GUNA Stomach PLUS
- •Tiny Tot Cough Syrup
- •Sleepy Time CP
- •Pericardium Triple Warmer Meridian Opener
- •Gallbladder Liver Meridian Opener
- •GI Distress
- •Nausia
- •Lung Detox
- •Cerebroforce
- •NV-HP
- •Diathesis I
- •Depressoforce
- •Renatone
- •Postpituapar
- •Nut Antigens
- •Endopar
- •Syphilitic Miasm
- •Sinutone
- •Diarrhea
- •Cold Sores
- •Sinu-S
- •Multi-System
- •Bact-In
- •Multi-Strain Cold and Flu Relief
- •First Aid mind and Body
- •D-112
- •D-152
- •Diaralia
- •Vermafuge -AG Lycopodium
- •Eczema Relief
- •Anti-Diarrhea Drops 2003
- •Sciatica Drops 2059
- •Wet Eczema Drops 2136
- •Amoeba/Protozoan Detox 6046
- •Geranium Combination 9224
- •Emvita 26
- •Cough and Cold Relief
- •Virus Defense Annakare
- •Homeoplex D
- •WHP Hay Fever
- •WHP Stress
- •Bestmade Natural Products BM33
- •Bestmade Natural Products BM176
- •Bestmade Natural Products BM197
- •Bestmade Natural Products BM201
- •Bestmade Natural Products BM240
- •Shallow Breathing Formula
- •GUNA Allergy
- •Virosode
- •Diathesis III
- •VAX
- •Neuroforce
- •Bio Biological Detox
- •Sinusforce-HP
- •Flower Antigens
- •Flutone
- •Breath HP
- •Lymph HP
- •Helleborus comp. A
- •Restful Legs
- •Food Additives
- •Inflammation-Fever
- •Homeopathic Moon drops
- •D-77
- •D-115
- •N-20
- •Day and Night Vitals
- •Met-Tox
- •Unda 48
- •MetDetox
- •Restless Leg Drops 2172
- •B09 Acute Virotox
- •B19 Acute Rescue
- •F25 LF-Chngs
- •R27 EYE
- •Agri-Chord
- •LV-FX
- •Emvita 21
- •Heavy Metal Detox T014
- •Homeoplex B
- •WHP Flu like Symptoms
- •Arsenicum Album 200ck
- •LUMO Heal Seasonal Flu Companion
- •Stress II
- •Bestmade Natural Products BM134
- •Mycotox
- •GUNA MOOD Support
- •Nausea Vomiting HP
- •Diarrhea CP
- •Nasal
- •Alumizen
- •Digestion
- •ANX HP
- •Adrenal Tonic
- •Somineze
- •Burn Aide
- •Epiforce E
- •Intestipar
- •Derma Rash HP
- •Histatone
- •Histapoll HP
- •Breathtone
- •GI Clear P
- •Hevert Detox Lymph
- •Dairy-Grain-Nightshades
- •Bug Bites - Itch Stopper
- •Viral
- •Lungs and Bronchial Relief
- •Anxiolix
- •Chron SINO
- •Sycosis Miasm Drops 2062
- •Mycotoxin Inhibitor 6020
- •Childhood Immunization Detox 6032
- •Trisenox
- •B21 Acute Rescue
- •N03 Exchem
- •CL-N
- •OP-P
- •Liver Boost
- •Spleen-Pro T018
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No Shortage
Industrial Uses
Used in 3 sectors as 2 functional roles.
- •Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant
- •Density modifier in Wood Product Manufacturing (100%)Processing—incorporation into article
- •Intermediate in Primary Metal Manufacturing (100%)Processing as a reactant
Chemical Identity
CAS1327-53-3
PubChem CID14888
DTXSIDDTXSID0020103
FormulaAs2O3
Mol. Weight197.841 g/mol
SMILES[O-2].[O-2].[O-2].[As+3].[As+3]
Data Sources
- EPA CompTox (DSSTox) · DTXSID0020103Retrieved 2026-04-06
- PubChem · compound 14888Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- FDA Drug ShortagesRetrieved 2026-06-13
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Arsenic oxide (As2O3) (CAS 1327-53-3) https://chemicalindependence.com/chemical/1327-53-3/ EPA CompTox (DSSTox): DTXSID0020103. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020103 PubChem: 14888. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/14888 EPA Chemical Data Reporting: 1327-53-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 1327-53-3. Retrieved 2026-06-13. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 281129 for CAS 1327-53-3. Reporting year: 2024. https://usatrade.census.gov/