Isomethyl-alpha-ionone

Drug ingredient

CAS 127-51-5

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$25M

Top sourceGermany 36%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291423 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291423, which covers 17 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

DE 36%GermanyCN 29%ChinaCH 19%SwitzerlandES 9%SpainIN 6%India

Mexico
Italy
Brazil
Slovakia
United Kingdom

Domestic parents -- activity not disclosed (2)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Berje

Reckitt Benckiser

EPA-registered importers (7)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Reckitt Benckiser Group · GB United Kingdom

Basf

Henkel Us Operations

International Flavors And Fragrances

Show all 7

P&G

Takasago

Why It Matters

Sectors

HealthMetals & MiningConsumer ProductsCore Chemicals

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Anubis Barcelona
•Anubis Barcelona Vital Line
•Anubis Barcelona Spa Line

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 1 functional role.

•Fragrance in All Other Chemical Product and Preparation Manufacturing (50%)Processing—repackaging
•Fragrance in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (3%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in Other (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS127-51-5

PubChem CID61073

DTXSIDDTXSID7027047

FormulaC14H22O

Mol. Weight206.32 g/mol

SMILESCC1=CCCC(C1C=C(C)C(=O)C)(C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID7027047Retrieved 2026-04-06
PubChem · compound 61073Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Isomethyl-alpha-ionone (CAS 127-51-5) https://chemicalindependence.com/chemical/127-51-5/ EPA CompTox (DSSTox): DTXSID7027047. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047 PubChem: 61073. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/61073 EPA Chemical Data Reporting: 127-51-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 127-51-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291423 for CAS 127-51-5. Reporting year: 2024. https://usatrade.census.gov/