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Sodium acetate

Drug ingredientActive Shortage

CAS 127-09-3

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 127-09-3
1 Na⁺
US productionCBI
Import value, 2024$64M
Top sourceNetherlands 37%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291529 · basket

EPA reports by year
2023
US production Confidential · Imports Confidential
2019
US production Confidential · Imports Confidential

These shares come from HS customs code 291529, which covers 45 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
NL 37%NetherlandsCN 16%ChinaCA 15%CanadaIT 7%ItalyGB 5%United Kingdom
EPA-registered manufacturers (5)
Aurorium
General Atomics International Services
Harcros Chemicals
Hawkins
Macdermid
Domestic parents -- activity not disclosed (1)
Kemira Water Solutions
EPA-registered importers (5)
Agfa
Brenntag
Chemical Distribution Network
Ecolab
Global Chemical Resources
13 FDA-registered drug labelers
Alcon Laboratories, Inc.
Avantor Performance Materials, LLC
B. Braun Medical Inc.
Baxter Healthcare Company
Baxter Healthcare Corporation
Fenwal, Inc.
Fresenius Kabi USA, LLC
Hahnemann Laboratories, INC.
Jost Chemical Co
Macco Organiques Inc
Merck KGaA
Merck Life Science Technologies (Nantong) Co., Ltd.
MILLA PHARMACEUTICALS INC.

Why It Matters

Sectors
HealthAgricultureFoodMetals & MiningPlastics & RubberTextilesConsumer ProductsCore Chemicals
Downstream Uses

Appears in 17 drug and cosmetic product listings (FDA).

  • •Sodium Acetate
  • •Natrum Aceticum
  • •Isolyte S
  • •Kabiven
  • •Plasma-Lyte 148 (pH 7.4)
  • •Solucion InterSol
  • •Isolyte P in Dextrose
  • •Clinimix E
Show all 17
  • •InterSol
  • •Multiple Electrolytes pH 5.5
  • •Multiple Electrolytes pH 7.4
  • •Plasma-Lyte A
  • •BSS
  • •Isolyte S pH 7.4
  • •Balanced Salt
  • •Physiolyte
  • •Perikabiven
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Sodium Acetate Injection

    Shortage listed since February 3, 2016

    Manufacturer reports: 1 unavailable, 1 limited, 2 available

See all current drug shortages

Industrial Uses

Used in 7 sectors as 10 functional roles.

  • •Soil amendments (fertilizers) in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (20%)Processing—incorporation into formulation, mixture, or reaction product
  • •pH regulating agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •pH regulating agent in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •Plating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Chelating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Etching agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Cleaning agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •pH regulating agent in Textiles, apparel, and leather manufacturing (100%)Processing—incorporation into article
  • •Catalyst in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •pH regulating agent in Other (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •Preservative in Food, beverage, and tobacco product manufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Flavoring and nutrient in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •pH regulating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Antioxidant in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS127-09-3
PubChem CID517045
DTXSIDDTXSID2027044
FormulaC2H3NaO2
Mol. Weight82.03 g/mol
SMILESCC(=O)[O-].[Na+]

Data Sources

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Brief citations

Sodium acetate (CAS 127-09-3) https://chemicalindependence.com/chemical/127-09-3/ EPA CompTox (DSSTox): DTXSID2027044. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044 PubChem: 517045. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/517045 EPA Chemical Data Reporting: 127-09-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 127-09-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 291529 for CAS 127-09-3. Reporting year: 2024. https://usatrade.census.gov/