encorafenib

Drug ingredient

CAS 1269440-17-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$2.0B

Top sourceIreland 63%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland

Portugal
Spain
Italy
Austria
Israel
Hungary
Canada
South Korea
Netherlands
Finland
Poland
Indonesia
Ukraine
Mexico
South Africa
Croatia
Greece
Taiwan
Hong Kong

7 FDA-registered drug labelers

Ardena US, LLC

Array BioPharma Inc.

Aurobindo Pharma Limited

Catalent Pharma Solutions, LLC

Finorga

MSN Laboratories Private Limited

VALARY LAB PRIVATE LIMITED

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Braftovi

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1269440-17-6

PubChem CID50922675

DTXSIDDTXSID00155347

FormulaC22H27ClFN7O4S

Mol. Weight540 g/mol

SMILESCC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC

Data Sources

PubChem · compound 50922675Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

encorafenib (CAS 1269440-17-6) https://chemicalindependence.com/chemical/1269440-17-6/ PubChem: 50922675. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/50922675 FDA National Drug Code directory: CAS 1269440-17-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293590 for CAS 1269440-17-6. Reporting year: 2024. https://usatrade.census.gov/