Dextromethorphan

Drug ingredient

CAS 125-71-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$111M

Top sourceIndia 28%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293349 · basket

These shares come from HS customs code 293349, which covers 94 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 28%IndiaCN 27%ChinaSE 12%SwedenKR 10%South KoreaGB 4%United Kingdom

Spain
Portugal
Germany
Netherlands
Israel
Australia
Taiwan
Lithuania
South Africa
Hong Kong

13 FDA-registered drug labelers

A-S Medication Solutions

American Health Packaging

Cardinal Health 107, LLC

Dasami Lab Private Limited

Divi's Laboratories Limited

DXM Pharmaceutical, Inc

Elysium Pharmaceuticals Ltd.

Exemed Pharmaceuticals

HY-GRO CHEMICALS PHARMTEK PVT LTD

Kramer Laboratories

Libi Pharm Ltd.

PAI Holdings, LLC dba PAI Pharma

RB Health (US) LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

•Guaifenesin DM
•Delsym
•Safetussin PM Nighttime Cough relief
•LIBI AIR Virlaza Dextromethorphan Cough Suppressant
•Delsym (Dextromethorphan)
•RoboTablets

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS125-71-3

PubChem CID5360696

DTXSIDDTXSID3022908

FormulaC18H25NO

Mol. Weight271.4 g/mol

SMILESCN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC

Data Sources

PubChem · compound 5360696Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Dextromethorphan (CAS 125-71-3) https://chemicalindependence.com/chemical/125-71-3/ PubChem: 5360696. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5360696 FDA National Drug Code directory: CAS 125-71-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293349 for CAS 125-71-3. Reporting year: 2024. https://usatrade.census.gov/