Hydrocodone

Drug ingredient

CAS 125-29-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$103M

Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain

Taiwan
New Zealand

1 FDA-registered drug labeler

Cambrex Charles City, Inc

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Homatropine Methylbromide and Hydrocodone Bitartrate Syrup
Shortage listed since September 11, 2025

See all current drug shortages

Chemical Identity

CAS125-29-1

PubChem CID5284569

DTXSIDDTXSID8023131

FormulaC18H21NO3

Mol. Weight299.4 g/mol

SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4

Data Sources

PubChem · compound 5284569Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Hydrocodone (CAS 125-29-1) https://chemicalindependence.com/chemical/125-29-1/ PubChem: 5284569. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5284569 FDA National Drug Code directory: CAS 125-29-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 125-29-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293911 for CAS 125-29-1. Reporting year: 2024. https://usatrade.census.gov/