Topotecan

Drug ingredient

CAS 123948-87-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$171M

Top sourceSwitzerland 40%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293979 · basket

These shares come from HS customs code 293979, which covers 60 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 40%SwitzerlandCN 18%ChinaIT 14%ItalyDE 13%GermanyIN 10%India

Australia
Poland
Belgium
Taiwan
Canada
Japan
Spain
Mexico
New Zealand
Slovenia
Israel

1 FDA-registered drug labeler

Accord Healthcare Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Topotecan

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS123948-87-8

PubChem CID60700

DTXSIDDTXSID3042685

FormulaC23H23N3O5

Mol. Weight421.4 g/mol

SMILESCCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

Data Sources

PubChem · compound 60700Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Topotecan (CAS 123948-87-8) https://chemicalindependence.com/chemical/123948-87-8/ PubChem: 60700. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/60700 FDA National Drug Code directory: CAS 123948-87-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293979 for CAS 123948-87-8. Reporting year: 2024. https://usatrade.census.gov/