Ethyl orthoformate

CAS 122-51-0

EPA’s 2023 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$384M

Import volumeCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Top sourceMalaysia 21%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291590 · basket

EPA reports by year

2023: US production Zero · Imports Confidential
2019: US production Zero · Imports 130.2K lb

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy

Singapore
Austria
United Kingdom
Philippines
Canada
Hungary
Turkey
Ukraine
Israel
Denmark
Czech Republic
Slovakia
Norway
Poland
Hong Kong
South Africa
Russia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Allchem Industries Holding

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Aceto Us

Milliken &

Why It Matters

Sectors

ConstructionPaints & CoatingsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 3 functional roles.

•Drier in Paint and Coating Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Adhesion/cohesion promoter in Asphalt Paving, Roofing, and Coating Materials Manufacturing (87%)Processing as a reactant
•Intermediate in All Other Chemical Product and Preparation Manufacturing (13%)Processing as a reactant

Vendor Pricing

$0.25/gCombi-Blocks, Inc.

CountryUnited States

Pack$250.00 / 1 kg

Purity98%

Vendors8 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

7 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$0.27	1 kg	98%
AA BLOCKS	United States	$0.28	1 kg	98%
Key Organics Ltd.	United Kingdom	$2.96	25 g	95%
Interbioscreen	Hong Kong	$17.00	10 g	95%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%

Chemical Identity

CAS122-51-0

PubChem CID31214

DTXSIDDTXSID8041957

FormulaC7H16O3

Mol. Weight148.2 g/mol

SMILESCCOC(OCC)OCC

Data Sources

EPA CompTox (DSSTox) · DTXSID8041957Retrieved 2026-04-06
PubChem · compound 31214Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ethyl orthoformate (CAS 122-51-0) https://chemicalindependence.com/chemical/122-51-0/ EPA CompTox (DSSTox): DTXSID8041957. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041957 PubChem: 31214. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/31214 EPA Chemical Data Reporting: 122-51-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 122-51-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291590 for CAS 122-51-0. Reporting year: 2024. https://usatrade.census.gov/