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4-Hydroxy-3-methoxybenzaldehyde

Drug ingredient

CAS 121-33-5

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

Molecular structure of 121-33-5
US productionCBI
Import value, 2024$108M
Top sourceChina 47%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.

Where It Comes From

Customs basis: HS 291241 · exact

EPA reports by year
2023
US production Confidential · Imports Confidential
2019
US production Confidential · Imports Confidential
Source Countries
CN 47%ChinaNO 29%NorwayID 13%IndonesiaIN 5%IndiaIT 3%Italy
EPA-registered manufacturers (2)
Syensqo Sa · BE Belgium
Solvay
Domestic parents -- activity not disclosed (1)
Reckitt Benckiser
EPA-registered importers (6)
Reckitt Benckiser Group · GB United Kingdom
Syensqo Sa · BE Belgium
Berje
Givaudan Fragrances
International Flavors And Fragrances
Show all 6
Tilley Distribution

Why It Matters

Sectors
Core ChemicalsHealthFoodConsumer Products
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Vanilla Planifolia
  • •Aquavit 1
  • •Vanilla
FDA Shortage Status
No FDA shortage records

Industrial Uses

Used in 5 sectors as 2 functional roles.

  • •Flavoring and nutrient in Food, beverage, and tobacco product manufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Fragrance in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
  • •Fragrance in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
  • •Fragrance in Not Known or Reasonably Ascertainable (100%)Not Known or Reasonably Ascertainable
  • •Fragrance in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.03/gAaron Chemicals LLC
CountryHong Kong
Pack$147.00 / 5 kg
Purity99%
Vendors38 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

37 more vendors
VendorCountry$/gPackPurity
AA BLOCKSUnited States$0.031 kg98%
A2B Chem LLCUnited States$0.031 kg98%
Angene ChemicalChina → Hong Kong$0.041 kg98%
BLD Pharmatech Co., LimitedUnited States$0.051 kg99%
BLD Pharmatech Ltd.China$0.051 kg99%
Ambeed, Inc.United States$0.051 kg99%
ChemsceneUnited States$0.051 kg—
Fluorochem EUGermany$0.061 kg95%
Fluorochem UKUnited Kingdom$0.07500 g95%
Apollo Scientific UKUnited Kingdom$0.07500 g99%
AK Scientific SpecializedUnited States$0.081 kg98%
Angene International LimitedUnited States$0.08500 g98%
Sigma-Aldrich (Rush Stock)Germany$0.0925 kg97%
Sigma-AldrichGermany$0.0925 kg97%
AK Scientific, Inc.United States$0.101 kg99%
ALFA AESARGermany$0.222.5 kg99%
Combi-Blocks, Inc.United States$0.251 kg98%
AldlabUnited States$0.5525 g95%
Manchester OrganicsUnited Kingdom$0.59500 g97%
MedChemExpress MCESweden$0.67100 g99.98%
MedKoo Biosciences, IncUnited States$5.00100 g98%
AstaTech (2 weeks)United States$6.005 g95%
InterbioscreenHong Kong$12.0010 g95%
Otava, Ltd.Ukraine$22.001 g95%
HTS Biochemie InnovationenGermany$120.0010 g95%
ChemNormChina$150.00100 mg98%
SpecsNetherlands$197.231 g90%
MolnovaChina$205.00200 mg99%
Labotest KGGermany$217.805000 mg90%
Apexbio Technology LLCUnited States$250.00200 mg99.98%
Vitas M Chemical LimitedHong Kong$360.001 g90%
ChemFacesChina$1500.0020 mg98%
Princeton BioMolecular Research (SC)United States$2900.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
ChemDiv, Inc.United States$4400.0090 mg90%
AsinexNetherlands$6461.40100 mg90%
Key Organics Ltd.United Kingdom$6900.0010 mg95%

Chemical Identity

CAS121-33-5
PubChem CID1183
DTXSIDDTXSID0021969
FormulaC8H8O3
Mol. Weight152.15 g/mol
SMILESCOC1=C(C=CC(=C1)C=O)O

Data Sources

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Brief citations

4-Hydroxy-3-methoxybenzaldehyde (CAS 121-33-5) https://chemicalindependence.com/chemical/121-33-5/ EPA CompTox (DSSTox): DTXSID0021969. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969 PubChem: 1183. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/1183 EPA Chemical Data Reporting: 121-33-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 121-33-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291241 for CAS 121-33-5. Reporting year: 2024. https://usatrade.census.gov/