Sofosbuvir

Drug ingredient

CAS 1190307-88-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

11 FDA-registered drug labelers

American Pacific Corporation

Asegua Therapeutics LLC

Cambrex Charles City, Inc

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Gilead Sciences, Inc

Hetero Labs Limited

Honour Lab Limited

MSN Life Sciences Private Limited

Patheon Inc.

ST Pharm Co., Ltd.

Teva API India Private Ltd

Why It Matters

Sectors

Health

Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

•Sovaldi
•Harvoni
•Sofosbuvir and Velpatasvir
•Epclusa
•Vosevi
•Ledipasvir and Sofosbuvir

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1190307-88-0

PubChem CID45375808

DTXSIDDTXSID701027632

FormulaC22H29FN3O9P

Mol. Weight529.5 g/mol

SMILESCC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Data Sources

PubChem · compound 45375808Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Sofosbuvir (CAS 1190307-88-0) https://chemicalindependence.com/chemical/1190307-88-0/ PubChem: 45375808. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/45375808 FDA National Drug Code directory: CAS 1190307-88-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 1190307-88-0. Reporting year: 2024. https://usatrade.census.gov/