Trametinib dimethyl sulfoxide

Drug ingredient

CAS 1187431-43-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

6 FDA-registered drug labelers

GlaxoSmithKline Manufacturing SpA

MSN Laboratories Private Limited

Novartis Pharma Schweizerhalle AG

Novartis Pharma Stein AG

Novartis Pharmaceuticals Corporation

VALARY LAB PRIVATE LIMITED

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Mekinist

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1187431-43-1

PubChem CID50992434

DTXSIDDTXSID30152223

FormulaC28H29FIN5O5S

Mol. Weight693.5 g/mol

SMILESCC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C

Data Sources

PubChem · compound 50992434Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Trametinib dimethyl sulfoxide (CAS 1187431-43-1) https://chemicalindependence.com/chemical/1187431-43-1/ PubChem: 50992434. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/50992434 FDA National Drug Code directory: CAS 1187431-43-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 1187431-43-1. Reporting year: 2024. https://usatrade.census.gov/